Combined Supplementation of Choline and Docosahexaenoic Acid during Pregnancy Enhances Neurodevelopment of Fetal Hippocampus
المؤلفون المشاركون
Thomas Rajarethnem, Huban
Megur Ramakrishna Bhat, Kumar
Jc, Malsawmzuali
Kumar Gopalkrishnan, Siva
Mugundhu Gopalram, Ramesh Babu
Rai, Kiranmai Sesappa
المصدر
Neurology Research International
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Choline is an essential nutrient for humans which plays an important role in structural integrity and signaling functions.
Docosahexaenoic acid (DHA) is a polyunsaturated fatty acid, highly enriched in cell membranes of the brain.
Dietary intake of choline or DHA alone by pregnant mothers directly affects fetal brain development and function.
But no studies show the efficacy of combined supplementation of choline and DHA on fetal neurodevelopment.
The aim of the present study was to analyze fetal neurodevelopment on combined supplementation of pregnant dams with choline and DHA.
Pregnant dams were divided into five groups: normal control [NC], saline control [SC], choline [C], DHA, and C + DHA.
Saline, choline, and DHA were given as supplements to appropriate groups of dams.
NC dams were undisturbed during entire gestation.
On postnatal day (PND) 40, brains were processed for Cresyl staining.
Pups from choline or DHA supplemented group showed significant (p<0.05) increase in number of neurons in hippocampus when compared to the same in NC and SC groups.
Moreover, pups from C + DHA supplemented group showed significantly higher number of neurons (p<0.001) in hippocampus when compared to the same in NC and SC groups.
Thus combined supplementation of choline and DHA during normal pregnancy enhances fetal hippocampal neurodevelopment better than supplementation of choline or DHA alone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Thomas Rajarethnem, Huban& Megur Ramakrishna Bhat, Kumar& Jc, Malsawmzuali& Kumar Gopalkrishnan, Siva& Mugundhu Gopalram, Ramesh Babu& Rai, Kiranmai Sesappa. 2017. Combined Supplementation of Choline and Docosahexaenoic Acid during Pregnancy Enhances Neurodevelopment of Fetal Hippocampus. Neurology Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1193428
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Thomas Rajarethnem, Huban…[et al.]. Combined Supplementation of Choline and Docosahexaenoic Acid during Pregnancy Enhances Neurodevelopment of Fetal Hippocampus. Neurology Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1193428
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Thomas Rajarethnem, Huban& Megur Ramakrishna Bhat, Kumar& Jc, Malsawmzuali& Kumar Gopalkrishnan, Siva& Mugundhu Gopalram, Ramesh Babu& Rai, Kiranmai Sesappa. Combined Supplementation of Choline and Docosahexaenoic Acid during Pregnancy Enhances Neurodevelopment of Fetal Hippocampus. Neurology Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1193428
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193428
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر