IL-10 Dampens the Th1 and Tc Activation through Modulating DC Functions in BCG Vaccination
المؤلفون المشاركون
Guo, Rui
Jia, Jing
Wei, Chaojun
Gao, Xiaoling
Xu, Hui
Jia, Yanjuan
Li, Yonghong
Wang, Wanxia
Wu, Yu
Li, Zhenhao
Wei, Zhenhong
Qi, Xiaoming
Li, Yuanting
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-06-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
BCG, the only registered vaccine against Mycobacterial Tuberculosis (TB) infection, has been questioned for its protective efficacy for decades.
Although lots of efforts were made to improve the BCG antigenicity, few studies were devoted to understand the role of host factors in the variability of the BCG protection.
Using the IL-10KO mice and pulmonary tuberculosis infection model, we have addressed the role of IL-10 in the BCG vaccination efficacy.
The data showed that IL-10-deficient dendritic cells (DCs) could promote the immune responses through upregulation of the surface costimulatory molecule expression and play an orchestra role through activating CD4+T cell.
IL-10-deficient mice had higher IFN γ, TNF α, and IL-6 production after BCG vaccination, which was consistent with the higher proportion of IFN γ+CD3+, IFN γ+CD4+, and IFN γ+CD8+ T cells in the spleen.
Particularly, the BCG-vaccinated IL-10KO mice showed less inflammation after TB challenge compared to WT mice, which was supported by the promoted Th1 and Tc, as well as the downregulated Treg responses in IL-10 deficiency.
In a conclusion, we demonstrated the negative relationship between Th1/Tc responses with IL-10 production.
IL-10 deficiency restored the type 1 immune response through DC activation, which provided better protection against TB infection.
Hence, our study offers the first experimental evidence that, contrary to the modulation of BCG, host immunity plays a critical role in the BCG protective efficacy against TB.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Hui& Jia, Yanjuan& Li, Yonghong& Wei, Chaojun& Wang, Wanxia& Guo, Rui…[et al.]. 2019. IL-10 Dampens the Th1 and Tc Activation through Modulating DC Functions in BCG Vaccination. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1193524
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Hui…[et al.]. IL-10 Dampens the Th1 and Tc Activation through Modulating DC Functions in BCG Vaccination. Mediators of Inflammation No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1193524
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Hui& Jia, Yanjuan& Li, Yonghong& Wei, Chaojun& Wang, Wanxia& Guo, Rui…[et al.]. IL-10 Dampens the Th1 and Tc Activation through Modulating DC Functions in BCG Vaccination. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1193524
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193524
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر