LincRNA Cox-2 Regulates Lipopolysaccharide-Induced Inflammatory Response of Human Peritoneal Mesothelial Cells via Modulating miR-21NF-κB Axis
المؤلفون المشاركون
Bian, Yaoyao
Yang, Lili
Zeng, Li
Li, Wen-Lin
Zhang, Bin
Li, Wen
Wang, Sen
Jiang, Shuling
Chen, Xi
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Postoperative peritoneal adhesion (PPA) is a common postoperative complication caused by any peritoneal inflammatory process.
This study aimed to identify the biological function of large intergenic non-coding RNAs (lincRNAs) Cox-2 in the inflammation reaction of adhesion formation.
The Cox-2 expression in peritoneal adhesion tissues and normal tissues was detected.
The human peritoneal mesothelium cells (HPMCs) were treated with lipopolysaccharide (LPS) to induce inflammatory injury.
The effect of Cox-2 suppression on cell viability, apoptosis and inflammatory factors of LPS induced HPMCs injury were explored.
The regulatory correlation between Cox-2 and miR-21, as well as the targeted genes of miR-21 were identified.
Meanwhile, the regulatory mechanism of Cox-2/miR-21 axis on NF-κB pathway was explored.
It indicated that Cox-2 was highly expressed in peritoneal adhesion tissues compared with that in normal tissues.
Suppression of Cox-2 ameliorated LPS induced HMPCs injury as cell viability was promoted, and cell apoptosis and the production of inflammatory factors were inhibited.
And suppression of Cox-2 reversed the LPS induced HPMCs injury by regulation of miR-21 negatively.
miR-21 was negatively correlated with TLR4, and TLR4 was predicted as target gene of miR-21.
Furthermore, the suppression of miR-21 on LPS induced HPMCs injury was reversed by knockdown of TLR4, which could inhibited the activation of NF-κB pathway axis.
It suggested that the effect of Cox-2 on LPS induced HPMCs injury was achieved by negatively regulation of miR-21 and targeted TLR4 through NF-κB pathway axis.
The findings may provide a new insight into preventing postoperative peritoneal adhesion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bian, Yaoyao& Yang, Lili& Zhang, Bin& Li, Wen& Wang, Sen& Jiang, Shuling…[et al.]. 2019. LincRNA Cox-2 Regulates Lipopolysaccharide-Induced Inflammatory Response of Human Peritoneal Mesothelial Cells via Modulating miR-21NF-κB Axis. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1193532
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bian, Yaoyao…[et al.]. LincRNA Cox-2 Regulates Lipopolysaccharide-Induced Inflammatory Response of Human Peritoneal Mesothelial Cells via Modulating miR-21NF-κB Axis. Mediators of Inflammation No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1193532
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bian, Yaoyao& Yang, Lili& Zhang, Bin& Li, Wen& Wang, Sen& Jiang, Shuling…[et al.]. LincRNA Cox-2 Regulates Lipopolysaccharide-Induced Inflammatory Response of Human Peritoneal Mesothelial Cells via Modulating miR-21NF-κB Axis. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1193532
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193532
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر