Safety and Efficacy of Extremely Low LDL-Cholesterol Levels and Its Prospects in Hyperlipidemia Management

المؤلفون المشاركون

Bandyopadhyay, Dhrubajyoti
Hajra, Adrija
Ashish, Kumar
Qureshi, Arshna
Ghosh, Raktim K.
Ghosh, Sudeshna
Heise, Lyndsey R.

المصدر

Journal of Lipids

العدد

المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2018-04-23

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري
علوم

الملخص EN

The risk of cardiovascular disease has been reported to have a linear relationship with LDL levels.

Additionally, the currently recommended LDL target goal of 70 mg/dl does not diminish the CV risk entirely leaving behind some residual risk.

Previous attempts to maximally lower the LDL levels with statin monotherapy have met dejection due to the increased side effects associated with the treatment.

Nevertheless, with the new advancements in clinical medicine, it has now become possible to bring down the LDL levels to as low as 15 mg/dl using PCSK9 monoclonal antibodies alone or in combination with statins.

The development of inclisiran, siRNA silencer targeting PCSK9 gene, is a one step forward in these endeavors.

Moreover, various studies aiming to lower the CV risk and mortality by lowering LDL levels have demonstrated encouraging results.

The current challenge is to explore this arena to redefine the target LDL levels, if required, to avoid any suboptimal treatment.

After thorough literature search in the PubMed, Embase, Scopus, and Google Scholar, we present this article to provide a brief overview of the safety and efficacy of lowering LDL below the current goal.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Bandyopadhyay, Dhrubajyoti& Qureshi, Arshna& Ghosh, Sudeshna& Ashish, Kumar& Heise, Lyndsey R.& Hajra, Adrija…[et al.]. 2018. Safety and Efficacy of Extremely Low LDL-Cholesterol Levels and Its Prospects in Hyperlipidemia Management. Journal of Lipids،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1193536

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Bandyopadhyay, Dhrubajyoti…[et al.]. Safety and Efficacy of Extremely Low LDL-Cholesterol Levels and Its Prospects in Hyperlipidemia Management. Journal of Lipids No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1193536

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Bandyopadhyay, Dhrubajyoti& Qureshi, Arshna& Ghosh, Sudeshna& Ashish, Kumar& Heise, Lyndsey R.& Hajra, Adrija…[et al.]. Safety and Efficacy of Extremely Low LDL-Cholesterol Levels and Its Prospects in Hyperlipidemia Management. Journal of Lipids. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1193536

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1193536