Interleukin-18 Expression Increases in the Aorta and Plasma of Patients with Acute Aortic Dissection
المؤلفون المشاركون
Chang, Chao
Xin, Shuanli
Liu, Jixiang
Hu, Haiying
Liu, Wenjing
Zhang, Guangtai
Hu, Huanli
Zhao, Xiufeng
Han, Liying
Duan, Liping
Huang, Xinshun
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-07-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Interleukin- (IL-) 18 is a proinflammatory cytokine related to cardiovascular diseases, including hypertension and atherosclerosis.
This study is aimed at determining whether IL-18 is related to aortic dissection (AD) and identifying the underlying mechanisms.
Methods.
IL-18 expression in human aorta samples from AD (n=8) and non-AD (NAD, n=7) patients was measured.
In addition, the IL-18, IL-6, interferon- (IFN-) γ, and IL-18-binding protein (IL-18BP) concentrations in plasma samples collected from the NAD and AD patients were detected.
The effects of IL-18 on macrophage differentiation and smooth muscle cell (SMC) apoptosis were investigated in vitro.
Results.
IL-18 expression was significantly increased in the aorta samples from the AD patients compared with those from the NAD patients, especially in the torn section.
Aortic IL-18 was mainly derived from macrophages and also partly derived from CD4+ T lymphocytes and vascular SMCs.
Plasma IL-18, IFN-γ, and IL-6 levels were significantly higher in the AD group than in the NAD group, and the IL-18 levels were positively correlated with the IFN-γ and IL-6 levels.
In addition, plasma IL-18BP and free IL-18 levels were also elevated in the AD group.
Linear regression analysis showed that the IL-18 level was independently associated with the presence of AD.
In addition, anti-mouse IL-18-neutralizing monoclonal antibodies (anti-IL-18 nAb) inhibited angiotensin II-induced M1 macrophage differentiation and SMC apoptosis in vitro.
Conclusion.
IL-18 may participate in AD by regulating macrophage differentiation and macrophage-induced SMC apoptosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Haiying& Zhang, Guangtai& Hu, Huanli& Liu, Wenjing& Liu, Jixiang& Xin, Shuanli…[et al.]. 2019. Interleukin-18 Expression Increases in the Aorta and Plasma of Patients with Acute Aortic Dissection. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1193542
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Haiying…[et al.]. Interleukin-18 Expression Increases in the Aorta and Plasma of Patients with Acute Aortic Dissection. Mediators of Inflammation No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1193542
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Haiying& Zhang, Guangtai& Hu, Huanli& Liu, Wenjing& Liu, Jixiang& Xin, Shuanli…[et al.]. Interleukin-18 Expression Increases in the Aorta and Plasma of Patients with Acute Aortic Dissection. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1193542
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193542
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر