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Epigenetic Regulation of IL-17-Induced Chemokines in Lung Epithelial Cells
المؤلفون المشاركون
Chen, Kong
Luo, Jiadi
An, Xiaojing
Yao, Yong
Erb, Carla
Ferguson, Annabel
Kolls, Jay K.
Fan, Songqing
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-03-17
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Epithelial cells are known to have barrier functions in multiple organs and regulate innate immune responses.
Airway epithelial cells respond to IL-17 by altering their transcriptional profiles and producing antimicrobial proteins and neutrophil chemoattractants.
Although IL-17 has been shown to promote inflammation through stabilizing mRNA of CXCR2 ligands, how IL-17 exerts its downstream effects on its target cells through epigenetic mechanisms is largely unknown.
Using primary human bronchial epithelial cells and immortalized epithelial cell line from both human and mouse, we demonstrated that IL-17-induced CXCR2 ligand production is dependent on histone acetylation specifically through repressing HDAC5.
Furthermore, the chemokine production induced by IL-17 is strictly dependent on the bromodomain and extraterminal domain (BET) family as BET inhibition abolished the IL-17A-induced proinflammatory chemokine production, indicating a pivotal role of the recognition of acetylated histones.
In combination with single-cell RNA-seq analysis, we revealed that the cell lines we employed represent specific lineages and their IL-17 responses were regulated differently by the DNA methylation mechanisms.
Taken together, our data strongly support that IL-17 sustains epithelial CXCR2 ligand production through epigenetic regulation and the therapeutic potential of interrupting histone modification as well as the recognition of modified histones could be evaluated in neutrophilic lung diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Luo, Jiadi& An, Xiaojing& Yao, Yong& Erb, Carla& Ferguson, Annabel& Kolls, Jay K.…[et al.]. 2019. Epigenetic Regulation of IL-17-Induced Chemokines in Lung Epithelial Cells. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1193611
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Luo, Jiadi…[et al.]. Epigenetic Regulation of IL-17-Induced Chemokines in Lung Epithelial Cells. Mediators of Inflammation No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1193611
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Luo, Jiadi& An, Xiaojing& Yao, Yong& Erb, Carla& Ferguson, Annabel& Kolls, Jay K.…[et al.]. Epigenetic Regulation of IL-17-Induced Chemokines in Lung Epithelial Cells. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1193611
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193611
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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