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Correlation between Serum IL-35 Levels and Bone Loss in Postmenopausal Women with Rheumatoid Arthritis
المؤلفون المشاركون
Li, Yuxuan
Xia, Liping
Shen, Hui
Lu, Jing
Yao, Lutian
Liu, Siyan
JishengWu, Siyan
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-26
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
IL-35 was reported as a crucial anti-inflammatory cytokine and could efficiently regulate bone metabolism in murine collagen-induced arthritis model.
However, the relationship between IL-35 and bone health in human rheumatoid arthritis (RA) has not been clarified.
In this study, the aim was to explore the correlations between IL-35 and bone loss in postmenopausal women with RA.
Methods.
The study included 76 postmenopausal women with RA and 53 healthy postmenopausal women as healthy controls (HCs).
Serum IL-35 levels were detected by enzyme-linked immunosorbent assay.
Bone mineral density (BMD) at lumbar spine 1-4 and at total hip was measured using dual-energy X-ray absorptiometry.
Alkaline phosphatase (ALP), β-isomerised carboxy-terminal cross-linking telopeptide of type I collagen (β-CTX), and 25-(OH) VitD3 were measured by turbidimetric inhibition immunoassay.
Results.
Serum IL-35 levels were increased compared with HCs, and it positively correlated with BMD and 25-(OH) VitD3 and negatively correlated with β-CTX in postmenopausal women with RA.
Furthermore, serum IL-35 levels in the increased ALP group were higher than those in the normal ALP group.
Conclusions.
IL-35, an important anti-inflammatory cytokine, may participate in the pathogenesis of bone loss in postmenopausal women with RA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yuxuan& Yao, Lutian& Liu, Siyan& JishengWu, Siyan& Xia, Liping& Shen, Hui…[et al.]. 2019. Correlation between Serum IL-35 Levels and Bone Loss in Postmenopausal Women with Rheumatoid Arthritis. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1193626
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yuxuan…[et al.]. Correlation between Serum IL-35 Levels and Bone Loss in Postmenopausal Women with Rheumatoid Arthritis. Mediators of Inflammation No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1193626
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yuxuan& Yao, Lutian& Liu, Siyan& JishengWu, Siyan& Xia, Liping& Shen, Hui…[et al.]. Correlation between Serum IL-35 Levels and Bone Loss in Postmenopausal Women with Rheumatoid Arthritis. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1193626
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193626
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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