Acute Strenuous Exercise Induces an Imbalance on Histone H4 AcetylationHistone Deacetylase 2 and Increases the Proinflammatory Profile of PBMC of Obese Individuals
المؤلفون المشاركون
Dorneles, Gilson Pires
Boeira, Maria Carolina R.
Schipper, Lucas L.
Silva, Ivy R. V.
Elsner, Viviane R.
Dal Lago, Pedro
Peres, Alessandra
Romão, Pedro R. T.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
This study evaluated the response of global histone H4 acetylation (H4ac), histone deacetylase 2 (HDAC2) activity, as well as the production of proinflammatory cytokines and monocyte phenotypes of lean and obese males after exercise.
Ten lean and ten obese sedentary men were submitted to one session of strenuous exercise, and peripheral blood mononuclear cells (PBMC) were stimulated in vitro with lipopolysaccharide (LPS).
Global H4ac levels, HDAC2 activity in PBMC, and IL-6, IL-8, and TNF-α production were analyzed.
Monocyte phenotype was determined in accordance with the expression of CD14 and CD16.
At rest, obese individuals presented higher frequency of proinflammatory CD14+CD16+ monocytes.
LPS induced a significant augment in global H4ac and in the production of IL-6, IL-8, and TNF-α mainly in obese individuals.
After exercise, the increased production of IL-8 and TNF-α and peripheral frequency of CD14+CD16+ were observed in both groups.
In addition, exercise also induced a significant hyperacetylation of histone H4 and decreased HDAC2 activity in both nonstimulated and LPS-stimulated PBMC of obese individuals.
Our data indicate that the obesity impacts on H4ac levels and that strenuous exercise leads to an enhanced chronic low-grade inflammation profile in obesity via an imbalance on H4ac/HDAC2.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dorneles, Gilson Pires& Boeira, Maria Carolina R.& Schipper, Lucas L.& Silva, Ivy R. V.& Elsner, Viviane R.& Dal Lago, Pedro…[et al.]. 2017. Acute Strenuous Exercise Induces an Imbalance on Histone H4 AcetylationHistone Deacetylase 2 and Increases the Proinflammatory Profile of PBMC of Obese Individuals. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193850
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dorneles, Gilson Pires…[et al.]. Acute Strenuous Exercise Induces an Imbalance on Histone H4 AcetylationHistone Deacetylase 2 and Increases the Proinflammatory Profile of PBMC of Obese Individuals. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1193850
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dorneles, Gilson Pires& Boeira, Maria Carolina R.& Schipper, Lucas L.& Silva, Ivy R. V.& Elsner, Viviane R.& Dal Lago, Pedro…[et al.]. Acute Strenuous Exercise Induces an Imbalance on Histone H4 AcetylationHistone Deacetylase 2 and Increases the Proinflammatory Profile of PBMC of Obese Individuals. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1193850
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193850
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر