Electrospun 4th-Generation Solid Dispersions of Poorly Water-Soluble Drug Utilizing Two Different Processes
المؤلفون المشاركون
Yu, Deng-Guang
Zhang, Zhu
Li, Wenbing
Wang, Guanghua
Qu, Yang-Lu
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Different from traditional solid dispersion (SD) for improving the dissolution rates of poorly water-soluble drugs, the upgraded 4th SD was developed to furnish a drug sustained-release profile.
In this work, two different kinds of 4th SDs were fabricated using two electrospinning processes.
One is a ternary SD (nanofibers F2) that consisted of ethyl cellulose (EC), polyethylene glycol 1000 (PEG), and tamoxifen citrate (TAM) from a modified coaxial process, and the other is a binary SD (nanofibers F1) which is comprised of EC and TAM from a single-fluid blending process.
Scanning electronic microscopic observations demonstrated that F2 (330±50 nm) showed a better quality than F1 (870±230 nm) in terms of size and size distribution although both of them had a smooth surface morphology and a cross section.
X-ray diffraction patterns verified that both SDs were amorphous nanocomposites owing to the favorable secondary interactions among these components, as suggested from the results of FTIR.
In vitro dissolution experiments indicated that F2 could furnish an improved drug sustained-release characteristics compared to F1, exhausting all the contained TAM and having weaker leveling-off late release.
The molecular behaviors of drug sustained-release from the binary 4th SD were suggested.
The protocols reported here paved an alternative way for developing novel functional nanomaterials for effective delivery of poorly water-soluble drugs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Zhu& Li, Wenbing& Wang, Guanghua& Qu, Yang-Lu& Yu, Deng-Guang. 2018. Electrospun 4th-Generation Solid Dispersions of Poorly Water-Soluble Drug Utilizing Two Different Processes. Journal of Nanomaterials،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1193858
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Zhu…[et al.]. Electrospun 4th-Generation Solid Dispersions of Poorly Water-Soluble Drug Utilizing Two Different Processes. Journal of Nanomaterials No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1193858
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Zhu& Li, Wenbing& Wang, Guanghua& Qu, Yang-Lu& Yu, Deng-Guang. Electrospun 4th-Generation Solid Dispersions of Poorly Water-Soluble Drug Utilizing Two Different Processes. Journal of Nanomaterials. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1193858
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193858
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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