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Mitochondrial Function and Mitophagy in the Elderly: Effects of Exercise
المؤلفون المشاركون
González-Gallego, Javier
De Paz, José A.
Cuevas, María J.
Moreira, Osvaldo C.
Estébanez, Brisamar
Martínez-Florez, Susana
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-16
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Aging is a natural, multifactorial and multiorganic phenomenon wherein there are gradual physiological and pathological changes over time.
Aging has been associated with a decrease of autophagy capacity and mitochondrial functions, such as biogenesis, dynamics, and mitophagy.
These processes are essential for the maintenance of mitochondrial structural integrity and, therefore, for cell life, since mitochondrial dysfunction leads to an impairment of energy metabolism and increased production of reactive oxygen species, which consequently trigger mechanisms of cellular senescence and apoptotic cell death.
Moreover, reduced mitochondrial function can contribute to age-associated disease phenotypes in model organisms and humans.
Literature data show beneficial effects of exercise on the impairment of mitochondrial biogenesis and dynamics and on the decrease in the mitophagic capacity associated to aging.
Thus, exercise could have effects on the major cell signaling pathways that are involved in the mitochondria quality and quantity control in the elderly.
Although it is known that several exercise protocols are able to modify the activity and turnover of mitochondria, further studies are necessary in order to better identify the mechanisms of interaction between mitochondrial functions, aging, and physical activity, as well as to analyze possible factors influencing these processes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moreira, Osvaldo C.& Estébanez, Brisamar& Martínez-Florez, Susana& De Paz, José A.& Cuevas, María J.& González-Gallego, Javier. 2017. Mitochondrial Function and Mitophagy in the Elderly: Effects of Exercise. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1193984
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moreira, Osvaldo C.…[et al.]. Mitochondrial Function and Mitophagy in the Elderly: Effects of Exercise. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1193984
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moreira, Osvaldo C.& Estébanez, Brisamar& Martínez-Florez, Susana& De Paz, José A.& Cuevas, María J.& González-Gallego, Javier. Mitochondrial Function and Mitophagy in the Elderly: Effects of Exercise. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1193984
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1193984
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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