Increased Oxidative Damage of RNA in Early-Stage Nephropathy in dbdb Mice
المؤلفون المشاركون
Cai, Jian-Ping
Hu, Guo-Xin
Xia, Meng-ming
Wang, Wanxia
Luo, Shun-Bin
Jiang, Ping
Hei, Ai-lian
Mao, Yong-Hui
Li, Chuan-Bao
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-19
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
To evaluate RNA oxidation in the early stage of diabetic nephropathy, we applied an accurate method based on isotope dilution high-performance liquid chromatography-triple quadruple mass spectrometry to analyze the oxidatively generated guanine nucleosides in renal tissue and urine from db/db mice of different ages.
We further investigated the relationship between these oxidative stress markers, microalbumin excretion, and histological changes.
We found that the levels of 8-oxo-7,8-dihydroguanosine (8-oxoGuo) and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) were increased in the urine and renal tissue of db/db mice and db/db mice with early symptoms of diabetic nephropathy suffered from more extensive oxidative damage than lean littermate control db/m mice.
Importantly, in contrast to the findings in db/m mice, the 8-oxoGuo levels in the urine and renal tissue of db/db mice were higher than those of 8-oxodGuo at four weeks.
These results indicate that RNA oxidation is more apparent than DNA oxidation in the early stage of diabetic nephropathy.
RNA oxidation may provide new insight into the pathogenesis of diabetic nephropathy, and urinary 8-oxoGuo may represent a novel, noninvasive, and easily detected biomarker of diabetic kidney diseases if further study could clarify its source and confirm these results in a large population study.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Wanxia& Luo, Shun-Bin& Jiang, Ping& Xia, Meng-ming& Hei, Ai-lian& Mao, Yong-Hui…[et al.]. 2017. Increased Oxidative Damage of RNA in Early-Stage Nephropathy in dbdb Mice. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194045
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Wanxia…[et al.]. Increased Oxidative Damage of RNA in Early-Stage Nephropathy in dbdb Mice. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194045
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Wanxia& Luo, Shun-Bin& Jiang, Ping& Xia, Meng-ming& Hei, Ai-lian& Mao, Yong-Hui…[et al.]. Increased Oxidative Damage of RNA in Early-Stage Nephropathy in dbdb Mice. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194045
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194045
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر