2-Deoxy-D-glucose Restore Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia via Modification of N-Linked Glycosylation in an Oxygen Tension-Independent Manner
المؤلفون المشاركون
Leni, Zaira
Arcaro, Alexandre
Ćwiek, Paulina
Dimitrova, Valeriya
Dulcey, Andrea S.
Zamboni, Nicola
Simillion, Cedric
Rossi, Geetha
Leibundgut, Kurt
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-26
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
In childhood acute lymphoblastic leukemia, treatment failure is associated with resistance to glucocorticoid agents.
Resistance to this class of drugs represents one of the strongest indicators of poor clinical outcome.
We show that leukemic cells, which are resistant to the glucocorticoid drug methylprednisolone, display a higher demand of glucose associated with a deregulation of metabolic pathways, in comparison to sensitive cells.
Interestingly, a combinatorial treatment of glucocorticoid and the glucose analog 2-deoxy-D-glucose displayed a synergistic effect in methylprednisolone-resistant cells, in an oxygen tension-independent manner.
Unlike solid tumors, where 2-deoxy-D-glucose promotes inhibition of glycolysis by hexokinase II exclusively under hypoxic conditions, we were able to show that the antileukemic effects of 2-deoxy-D-glucose are far more complex in leukemia.
We demonstrate a hexokinase II-independent cell viability decrease and apoptosis induction of the glucose analog in leukemia.
Additionally, due to the structural similarity of 2-deoxy-D-glucose with mannose, we could confirm that the mechanism by which 2-deoxy-D-glucose predominantly acts in leukemia is via modification in N-linked glycosylation, leading to endoplasmic reticulum stress and consequently induction of the unfolded protein response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Leni, Zaira& Ćwiek, Paulina& Dimitrova, Valeriya& Dulcey, Andrea S.& Zamboni, Nicola& Simillion, Cedric…[et al.]. 2017. 2-Deoxy-D-glucose Restore Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia via Modification of N-Linked Glycosylation in an Oxygen Tension-Independent Manner. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1194079
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Leni, Zaira…[et al.]. 2-Deoxy-D-glucose Restore Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia via Modification of N-Linked Glycosylation in an Oxygen Tension-Independent Manner. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1194079
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Leni, Zaira& Ćwiek, Paulina& Dimitrova, Valeriya& Dulcey, Andrea S.& Zamboni, Nicola& Simillion, Cedric…[et al.]. 2-Deoxy-D-glucose Restore Glucocorticoid Sensitivity in Acute Lymphoblastic Leukemia via Modification of N-Linked Glycosylation in an Oxygen Tension-Independent Manner. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1194079
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194079
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر