MicroRNA-93 Regulates Hypoxia-Induced Autophagy by Targeting ULK1
المؤلفون المشاركون
Zhang, Liangqing
Feng, Du
He, Pengcheng
Li, Wen
Yang, Yue
Ba, Zhaoyu
Li, Shupeng
Chen, Hao
Hou, Xiaoyan
Ma, Linlin
Jiang, Lei
Li, Longxuan
He, Rong-Rong
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-03
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The expression of the core autophagy kinase, Unc51-like kinase 1 (ULK1), is regulated transcriptionally and translationally by starvation-induced autophagy.
However, how ULK1 is regulated during hypoxia is not well understood.
Previously, we showed that ULK1 expression is induced by hypoxia stress.
Here, we report a new ULK1-modulating microRNA, miR-93; its transcription is negatively correlated with the translation of ULK1 under hypoxic condition.
miR-93 targets ULK1 and reduces its protein levels under hypoxia condition.
miR-93 also inhibits hypoxia-induced autophagy by preventing LC3-I to LC3-II transition and P62 degradation; these processes are reversed by the overexpression of an endogenous miR-93 inhibitor.
Re-expression of ULK1 without miR-93 response elements restores the hypoxia-induced autophagy which is inhibited by miR-93.
Finally, we detected the effects of miR-93 on cell viability and apoptosis in noncancer cell lines and cancer cells.
We found that miR-93 sustains the viability of MEFs (mouse embryonic fibroblasts) and inhibits its apoptosis under hypoxia.
Thus, we conclude that miR-93 is involved in hypoxia-induced autophagy by regulating ULK1.
Our results provide a new angle to understand the complicated regulation of the key autophagy kinase ULK1 during different stress conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Wen& Yang, Yue& Ba, Zhaoyu& Li, Shupeng& Chen, Hao& Hou, Xiaoyan…[et al.]. 2017. MicroRNA-93 Regulates Hypoxia-Induced Autophagy by Targeting ULK1. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194121
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Wen…[et al.]. MicroRNA-93 Regulates Hypoxia-Induced Autophagy by Targeting ULK1. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1194121
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Wen& Yang, Yue& Ba, Zhaoyu& Li, Shupeng& Chen, Hao& Hou, Xiaoyan…[et al.]. MicroRNA-93 Regulates Hypoxia-Induced Autophagy by Targeting ULK1. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194121
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194121
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر