Ammonium Bisphosphonate Polymeric Magnetic Nanocomplexes for Platinum Anticancer Drug Delivery and Imaging with Potential Hyperthermia and Temperature-Dependent Drug Release
المؤلفون المشاركون
Zhang, Rui
Fellows, Benjamin
Pothayee, Nikorn
Hu, Nan
Pothayee, Nipon
Jo, Ami
Bohórquez, Ana C.
Rinaldi, Carlos
Mefford, Olin Thompson
Davis, Richey M.
Riffle, Judy S.
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-08-05
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Novel magnetite-ammonium bisphosphonate graft ionic copolymer nanocomplexes (MGICs) have been developed for potential drug delivery, magnetic resonance imaging, and hyperthermia applications.
The complexes displayed relatively uniform sizes with narrow size distributions upon self-assembly in aqueous media, and their sizes were stable under simulated physiological conditions for at least 7 days.
The anticancer drugs, cisplatin and carboplatin, were loaded into the complexes, and sustained release of both drugs was observed.
The transverse NMR relaxivities (r2s) of the complexes were 244 s−1 (mM Fe)−1 which is fast compared to either the commercial T2-weighted MRI agent Feridex IV® or our previously reported magnetite-block ionomer complexes.
Phantom MRI images of the complexes demonstrated excellent negative contrast effects of such complexes.
Thus, the bisphosphonate-bearing MGICs could be promising candidates for dual drug delivery and magnetic resonance imaging.
Moreover, the bisphosphonate MGICs generate heat under an alternating magnetic field of 30 kA·m−1 at 206 kHz.
The temperature of the MGIC dispersion in deionized water increased from 37 to 41°C after exposure to the magnetic field for 10 minutes, corresponding to a specific absorption rate of 77.0 W·g−1.
This suggests their potential as hyperthermia treatment agents as well as the possibility of temperature-dependent drug release, making MGICs more versatile in potential drug delivery applications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Rui& Fellows, Benjamin& Pothayee, Nikorn& Hu, Nan& Pothayee, Nipon& Jo, Ami…[et al.]. 2018. Ammonium Bisphosphonate Polymeric Magnetic Nanocomplexes for Platinum Anticancer Drug Delivery and Imaging with Potential Hyperthermia and Temperature-Dependent Drug Release. Journal of Nanomaterials،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1194126
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Rui…[et al.]. Ammonium Bisphosphonate Polymeric Magnetic Nanocomplexes for Platinum Anticancer Drug Delivery and Imaging with Potential Hyperthermia and Temperature-Dependent Drug Release. Journal of Nanomaterials No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1194126
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Rui& Fellows, Benjamin& Pothayee, Nikorn& Hu, Nan& Pothayee, Nipon& Jo, Ami…[et al.]. Ammonium Bisphosphonate Polymeric Magnetic Nanocomplexes for Platinum Anticancer Drug Delivery and Imaging with Potential Hyperthermia and Temperature-Dependent Drug Release. Journal of Nanomaterials. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1194126
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194126
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر