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Effect of Vitamin D Receptor Activation on the AGERAGE System and Myeloperoxidase in Chronic Kidney Disease Patients
المؤلفون المشاركون
Mallamaci, Francesca
Tripepi, G.
Zoccali, C.
Torino, Claudia
Pizzini, Patrizia
Cutrupi, Sebastiano
Tripepi, Rocco
Vilasi, Antonio
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-06
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Vitamin D receptor (VDR) activation has been reported to increase circulating levels of the advanced glycation end products (AGE) and their decoy receptor (RAGE).
However, until now, the effect of VDR activation on AGE and RAGE has not been tested in the setting of a randomized, double-blind clinical trial.
We have therefore analyzed the effect of VDR activation by paricalcitol on pentosidine, S100A12/ENRAGE, and RAGE and on established biomarkers of oxidative stress like myeloperoxidase in CKD patients in the PENNY trial.
At baseline, human S100A12/ENRAGE, RAGE, and myeloperoxidase, but not pentosidine, were intercorrelated, and the association between S100A12/ENRAGE and myeloperoxidase (r=0.71, P<0.001) was the strongest among these correlations.
Paricalcitol failed to modify biomarkers of the AGE/RAGE system and myeloperoxidase in unadjusted and adjusted analyses by the generalized linear model (GLM).
No effect modification by other risk factors was registered.
Paricalcitol does not modify biomarkers of the AGE/RAGE system and myeloperoxidase in CKD patients.
The apparent increase in RAGE levels by VDR activation reported in previous uncontrolled studies is most likely due to confounding factors rather than to VDR activation per se.
This trial is registered with NCT01680198.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Torino, Claudia& Pizzini, Patrizia& Cutrupi, Sebastiano& Tripepi, Rocco& Vilasi, Antonio& Tripepi, G.…[et al.]. 2017. Effect of Vitamin D Receptor Activation on the AGERAGE System and Myeloperoxidase in Chronic Kidney Disease Patients. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1194167
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Torino, Claudia…[et al.]. Effect of Vitamin D Receptor Activation on the AGERAGE System and Myeloperoxidase in Chronic Kidney Disease Patients. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1194167
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Torino, Claudia& Pizzini, Patrizia& Cutrupi, Sebastiano& Tripepi, Rocco& Vilasi, Antonio& Tripepi, G.…[et al.]. Effect of Vitamin D Receptor Activation on the AGERAGE System and Myeloperoxidase in Chronic Kidney Disease Patients. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1194167
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194167
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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