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Targeting Oxidative Stress for Treatment of Glaucoma and Optic Neuritis
المؤلفون المشاركون
Noro, Takahiko
Kimura, Atsuko
Namekata, Kazuhiko
Guo, Xiaoli
Harada, Chikako
Harada, Takayuki
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Glaucoma is a neurodegenerative disease of the eye and it is one of the leading causes of blindness.
Glaucoma is characterized by progressive degeneration of retinal ganglion cells (RGCs) and their axons, namely, the optic nerve, usually associated with elevated intraocular pressure (IOP).
Current glaucoma therapies target reduction of IOP, but since RGC death is the cause of irreversible vision loss, neuroprotection may be an effective strategy for glaucoma treatment.
One of the risk factors for glaucoma is increased oxidative stress, and drugs with antioxidative properties including valproic acid and spermidine, as well as inhibition of apoptosis signal-regulating kinase 1, an enzyme that is involved in oxidative stress, have been reported to prevent glaucomatous retinal degeneration in mouse models of glaucoma.
Optic neuritis is a demyelinating inflammation of the optic nerve that presents with visual impairment and it is commonly associated with multiple sclerosis, a chronic demyelinating disease of the central nervous system.
Although steroids are commonly used for treatment of optic neuritis, reduction of oxidative stress by approaches such as gene therapy is effective in ameliorating optic nerve demyelination in preclinical studies.
In this review, we discuss oxidative stress as a therapeutic target for glaucoma and optic neuritis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kimura, Atsuko& Namekata, Kazuhiko& Guo, Xiaoli& Noro, Takahiko& Harada, Chikako& Harada, Takayuki. 2017. Targeting Oxidative Stress for Treatment of Glaucoma and Optic Neuritis. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1194169
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kimura, Atsuko…[et al.]. Targeting Oxidative Stress for Treatment of Glaucoma and Optic Neuritis. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1194169
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kimura, Atsuko& Namekata, Kazuhiko& Guo, Xiaoli& Noro, Takahiko& Harada, Chikako& Harada, Takayuki. Targeting Oxidative Stress for Treatment of Glaucoma and Optic Neuritis. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1194169
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194169
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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