Markers of Oxidative Stress and Inflammation in Ascites and Plasma in Patients with Platinum-Sensitive, Platinum-Resistant, and Platinum-Refractory Epithelial Ovarian Cancer
المؤلفون المشاركون
Rodríguez-Carrizalez, Adolfo Daniel
Miranda-Díaz, Alejandra Guillermina
Carrillo-Ibarra, Sandra
Sifuentes-Franco, Sonia
José Alberto, Castellanos-González
Cantón-Romero, Juan Carlos
Bañuelos-Ramírez, Jose Luis
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-07
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Diverse proinflammatory biomarkers and oxidative stress are strongly associated with advanced epithelial ovarian cancer (EOC).
Objective.
To determine the behavior of markers of oxidative stress and inflammation in plasma and ascites fluid in patients with platinum-sensitive, platinum-resistant, and platinum-refractory EOC.
Methods.
A prospective cohort study.
The colorimetric method was used to determine levels of the markers 8-isoprostanes (8-IP), lipid peroxidation products (LPO), and total antioxidant capacity (TAC) in plasma and ascites fluid; and with ELISA, the levels of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) were determined in patients with EOC.
Results.
In ascites fluid, a significant increase in 8-IP versus baseline plasma levels was found (p=0.002).
There was an important leakage of the TAC levels in ascites fluid versus baseline plasma levels (p<0.001).
The IL-6 was elevated in ascites fluid versus baseline plasma levels (p=0.003), and there were diminished levels of TNF-α in ascites fluid versus baseline plasma levels (p=0.001).
Discussion.
We hypothesize that the ascites fluid influences the behavior and dissemination of the tumor.
Deregulation between oxidants, antioxidants, and the proinflammatory cytokines was found to vary among platinum-sensitive, platinum-resistant, and platinum-refractory patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cantón-Romero, Juan Carlos& Miranda-Díaz, Alejandra Guillermina& Bañuelos-Ramírez, Jose Luis& Carrillo-Ibarra, Sandra& Sifuentes-Franco, Sonia& José Alberto, Castellanos-González…[et al.]. 2017. Markers of Oxidative Stress and Inflammation in Ascites and Plasma in Patients with Platinum-Sensitive, Platinum-Resistant, and Platinum-Refractory Epithelial Ovarian Cancer. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1194180
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cantón-Romero, Juan Carlos…[et al.]. Markers of Oxidative Stress and Inflammation in Ascites and Plasma in Patients with Platinum-Sensitive, Platinum-Resistant, and Platinum-Refractory Epithelial Ovarian Cancer. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1194180
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cantón-Romero, Juan Carlos& Miranda-Díaz, Alejandra Guillermina& Bañuelos-Ramírez, Jose Luis& Carrillo-Ibarra, Sandra& Sifuentes-Franco, Sonia& José Alberto, Castellanos-González…[et al.]. Markers of Oxidative Stress and Inflammation in Ascites and Plasma in Patients with Platinum-Sensitive, Platinum-Resistant, and Platinum-Refractory Epithelial Ovarian Cancer. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1194180
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194180
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر