Curcumin Reverses the Diazepam-Induced Cognitive Impairment by Modulation of Oxidative Stress and ERK 12NF-κB Pathway in Brain
المؤلفون المشاركون
Sevastre-Berghian, Alexandra C.
Făgărăsan, Vlad
Toma, Vlad A.
Bâldea, Ioana
Olteanu, Diana
Moldovan, Remus
Decea, Nicoleta
Filip, Gabriela A.
Clichici, Simona V.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-02
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Oxidative stress and inflammation can be involved in cognitive dysfunction associated with neurodegenerative disorders.
Diazepam (DZP) administration has been chosen to simulate the memory impairment.
The aim of this study was to evaluate the effects of curcumin (CUR) on spatial cognition, ambulatory activity, and blood and brain oxidative stress levels.
The ERK/NF-κB signaling pathway and the histopathological changes in the hippocampus and frontal lobe, in diazepam-treated rats, were also analyzed.
The animals were divided into 4 groups: control, carboxymethylcellulose (CMC) + CUR, CMC + DZP, and CUR + CMC + DZP.
CUR (150 mg/kg b.w.) was orally administered for 28 days.
DZP (2 mg/kg b.w.) was intraperitoneally administered 20 minutes before the behavioral tests (open field test, Y-maze, and elevated plus maze).
CUR improved the spontaneous alternation behavior, decreased the oxidative stress levels, both in the blood and in the hippocampus, and downregulated the extracellular signal-regulated kinase (ERK 1/2)/nuclear transcription factor- (NF-) κB/pNF-κB pathway in the hippocampus and the iNOS expression in the hippocampus and frontal lobe of the DZP-treated rats.
Histopathologically, no microscopic changes were found.
The immunohistochemical signal of iNOS decreased in the DZP and CUR-treated group.
Thus, our findings suggest that curcumin administration may improve the cognitive performance and may also have an antioxidant effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sevastre-Berghian, Alexandra C.& Făgărăsan, Vlad& Toma, Vlad A.& Bâldea, Ioana& Olteanu, Diana& Moldovan, Remus…[et al.]. 2017. Curcumin Reverses the Diazepam-Induced Cognitive Impairment by Modulation of Oxidative Stress and ERK 12NF-κB Pathway in Brain. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1194219
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sevastre-Berghian, Alexandra C.…[et al.]. Curcumin Reverses the Diazepam-Induced Cognitive Impairment by Modulation of Oxidative Stress and ERK 12NF-κB Pathway in Brain. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1194219
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sevastre-Berghian, Alexandra C.& Făgărăsan, Vlad& Toma, Vlad A.& Bâldea, Ioana& Olteanu, Diana& Moldovan, Remus…[et al.]. Curcumin Reverses the Diazepam-Induced Cognitive Impairment by Modulation of Oxidative Stress and ERK 12NF-κB Pathway in Brain. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1194219
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194219
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر