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Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases
المؤلفون المشاركون
Eid, Assaad
Munusamy, Shankar
Pasha, Mazhar
Eid, Ali H.
Gorin, Yves
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Sestrin2 (SESN2), a highly conserved stress-inducible metabolic protein, is known to repress reactive oxygen species (ROS) and provide cytoprotection against various noxious stimuli including genotoxic and oxidative stress, endoplasmic reticulum (ER) stress, and hypoxia.
Studies demonstrate that the upregulation of Sestrin2 under conditions of oxidative stress augments autophagy-directed degradation of Kelch-like ECH-associated protein 1 (Keap1), which targets and breaks down nuclear erythroid-related factor 2 (Nrf2), a key regulator of various antioxidant genes.
Moreover, ER stress and hypoxia are shown to induce Sestrins, which ultimately reduce cellular ROS levels.
Sestrin2 also plays a pivotal role in metabolic regulation through activation of the key energy sensor AMP-dependent protein kinase (AMPK) and inhibition of mammalian target of rapamycin complex 1 (mTORC1).
Other downstream effects of Sestrins include autophagy activation, antiapoptotic effects in normal cells, and proapoptotic effects in cancer cells.
As perturbations in the aforementioned pathways are well documented in multiple diseases, Sestrin2 might serve as a potential therapeutic target for various diseases.
Thus, the aim of this review is to discuss the upstream regulators and the downstream effectors of Sestrins and to highlight the significance of Sestrin2 as a biomarker and a therapeutic target in diseases such as metabolic disorders, cardiovascular and neurodegenerative diseases, and cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pasha, Mazhar& Eid, Ali H.& Eid, Assaad& Gorin, Yves& Munusamy, Shankar. 2017. Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1194310
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pasha, Mazhar…[et al.]. Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1194310
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pasha, Mazhar& Eid, Ali H.& Eid, Assaad& Gorin, Yves& Munusamy, Shankar. Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1194310
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194310
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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