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Triethylenetetramine Synergizes with Pharmacologic Ascorbic Acid in Hydrogen Peroxide Mediated Selective Toxicity to Breast Cancer Cell
المؤلفون المشاركون
Delplancke, Thibaut D. J.
Qi, Hongbo
Tong, Chao
Baker, Philip N.
Wang, Lianlian
Luo, Xiaofang
Li, Cong
Huang, Yubing
Xu, Ping
Lloyd-Davies, Laetitia H.
Peng, Chuan
Gao, Rufei
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-08
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Breast cancer is characterized by overexpression of superoxide dismutase (SOD) and downregulation of catalase and more resistance to hydrogen peroxide (H2O2) than normal cells.
Thus, relatively high H2O2 promotes breast cancer cell growth and proliferation.
However, excessive intracellular H2O2 leads to death of breast cancer cells.
In cancer cells, high level ascorbic acid (Asc) is able to be autoxidized and thus provides an electron to oxygen to generate H2O2.
In the present study, we demonstrated that triethylenetetramine (TETA) enhances Asc autoxidation and thus elevates H2O2 production in MCF-7 cells.
Furthermore, Asc/TETA combination significantly impaired cancer cell viability, while having much milder effects on normal cells, indicating Asc/TETA could be a promising therapy for breast cancer.
Moreover, SOD1 and N-acetyl-L-cysteine failed to improve MCF-7 cells viability in the presence of Asc/TETA, while catalase significantly inhibited the cytotoxicity of Asc/TETA to breast cancer cells, strongly suggesting that the selective cytotoxicity of Asc/TETA to cancer cells is H2O2-dependent.
In addition, Asc/TETA induces RAS/ERK downregulation in breast cancer cells.
Animal studies confirmed that Asc/TETA effectively suppressed tumor growth in vivo.
In conclusion, TETA synergizes pharmacologic Asc autoxidation and H2O2 overproduction in breast cancer cells, which suppresses RAS/ERK pathway and results in apoptosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Lianlian& Luo, Xiaofang& Li, Cong& Huang, Yubing& Xu, Ping& Lloyd-Davies, Laetitia H.…[et al.]. 2017. Triethylenetetramine Synergizes with Pharmacologic Ascorbic Acid in Hydrogen Peroxide Mediated Selective Toxicity to Breast Cancer Cell. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194362
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Lianlian…[et al.]. Triethylenetetramine Synergizes with Pharmacologic Ascorbic Acid in Hydrogen Peroxide Mediated Selective Toxicity to Breast Cancer Cell. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1194362
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Lianlian& Luo, Xiaofang& Li, Cong& Huang, Yubing& Xu, Ping& Lloyd-Davies, Laetitia H.…[et al.]. Triethylenetetramine Synergizes with Pharmacologic Ascorbic Acid in Hydrogen Peroxide Mediated Selective Toxicity to Breast Cancer Cell. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1194362
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194362
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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