Cellular Homeostasis and Antioxidant Response in Epithelial HT29 Cells on Titania Nanotube Arrays Surface
المؤلفون المشاركون
SMN Mydin, Rabiatul Basria
Sreekantan, Srimala
Hazan, Roshasnorlyza
Farid Wajidi, Mustafa Fadzil
Mat, Ishak
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Cell growth and proliferative activities on titania nanotube arrays (TNA) have raised alerts on genotoxicity risk.
Present toxicogenomic approach focused on epithelial HT29 cells with TNA surface.
Fledgling cell-TNA interaction has triggered G0/G1 cell cycle arrests and initiates DNA damage surveillance checkpoint, which possibly indicated the cellular stress stimuli.
A profound gene regulation was observed to be involved in cellular growth and survival signals such as p53 and AKT expressions.
Interestingly, the activation of redox regulator pathways (antioxidant defense) was observed through the cascade interactions of GADD45, MYC, CHECK1, and ATR genes.
These mechanisms furnish to protect DNA during cellular division from an oxidative challenge, set in motion with XRRC5 and RAD50 genes for DNA damage and repair activities.
The cell fate decision on TNA-nanoenvironment has been reported to possibly regulate proliferative activities via expression of p27 and BCL2 tumor suppressor proteins, cogent with SKP2 and BCL2 oncogenic proteins suppression.
Findings suggested that epithelial HT29 cells on the surface of TNA may have a positive regulation via cell-homeostasis mechanisms: a careful circadian orchestration between cell proliferation, survival, and death.
This nanomolecular knowledge could be beneficial for advanced medical applications such as in nanomedicine and nanotherapeutics.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
SMN Mydin, Rabiatul Basria& Sreekantan, Srimala& Hazan, Roshasnorlyza& Farid Wajidi, Mustafa Fadzil& Mat, Ishak. 2017. Cellular Homeostasis and Antioxidant Response in Epithelial HT29 Cells on Titania Nanotube Arrays Surface. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1194404
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
SMN Mydin, Rabiatul Basria…[et al.]. Cellular Homeostasis and Antioxidant Response in Epithelial HT29 Cells on Titania Nanotube Arrays Surface. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1194404
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
SMN Mydin, Rabiatul Basria& Sreekantan, Srimala& Hazan, Roshasnorlyza& Farid Wajidi, Mustafa Fadzil& Mat, Ishak. Cellular Homeostasis and Antioxidant Response in Epithelial HT29 Cells on Titania Nanotube Arrays Surface. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1194404
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194404
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر