circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis
المؤلفون المشاركون
Pan, Qin
Fan, Jian-Gao
Sun, Fang
Guo, Xing-Ya
Wang, Yu-Qin
Chen, Jian-Neng
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-05
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Hepatic steatosis reflects the miRNA-related pathological disorder with triglyceride accumulation and lipid peroxidation, which leads to nonalcoholic steatohepatitis, liver fibrosis/cirrhosis, and even hepatocellular carcinoma.
Circular RNA (circRNA)/miRNA interaction reveals a novel layer of epigenetic regulation, yet the miRNA-targeting circRNA remains uncertain in hepatic steatosis.
Here, we uncover circRNA_0046367 to be endogenous modulator of miR-34a that underlies hepatic steatosis.
In contrast to its expression loss during the hepatocellular steatosis in vivo and in vitro, circRNA_0046367 normalization abolished miR-34a’s inhibitory effect on peroxisome proliferator-activated receptor α (PPARα) via blocking the miRNA/mRNA interaction with miRNA response elements (MREs).
PPARα restoration led to the transcriptional activation of genes associated with lipid metabolism, including carnitine palmitoyltransferase 2 (CPT2) and acyl-CoA binding domain containing 3 (ACBD3), and then resulted in the steatosis resolution.
Hepatotoxicity of steatosis-related lipid peroxidation, being characterized by mitochondrial dysfunction, growth arrest, and apoptosis, is resultantly prevented after the circRNA_0046367 administration.
These findings indicate a circRNA_0046367/miR-34a/PPARα regulatory system underlying hepatic steatosis.
Normalized expression of circRNA_0046367 may ameliorate the lipoxidative stress on the basis of steatosis attenuation.
circRNA_0046367, therefore, is suggested to be potential approach to the therapy of lipid peroxidative damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Guo, Xing-Ya& Chen, Jian-Neng& Sun, Fang& Wang, Yu-Qin& Pan, Qin& Fan, Jian-Gao. 2017. circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1194499
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Guo, Xing-Ya…[et al.]. circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1194499
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Guo, Xing-Ya& Chen, Jian-Neng& Sun, Fang& Wang, Yu-Qin& Pan, Qin& Fan, Jian-Gao. circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1194499
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194499
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر