Cytokines Genotype-Phenotype Correlation in Nonalcoholic Steatohepatitis
المؤلفون المشاركون
Bocsan, Ioana Corina
Milaciu, Mircea Vasile
Pop, Raluca Maria
Vesa, Stefan Cristian
Ciumarnean, Lorena
Matei, Daniela Maria
Buzoianu, Anca Dana
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
NASH consists in lipid accumulation in hepatocytes that trigger oxidative stress, secretion of proinflammatory cytokines leading to steatohepatitis (NASH).
The study aimed to investigate the levels of proinflammatory (TNF-α and IL-6) along with anti-inflammatory cytokine IL-10 in patients with NASH and to correlate the cytokines’ level with their polymorphism.
Sixty-six patients with NASH and 30 healthy volunteers were included in the study.
The plasmatic level of IL-6, IL-10, and TNF-α were determined by ELISA.
IL-10 -1082 G/A, IL-6 -174 G/C, and TNF-α -308 G/A polymorphisms were determined using the PCR-RFLP technique.
IL-6, TNF-α, and CRP levels were significantly higher in patients with NASH.
There was a positive correlation between proinflammatory cytokines and a negative correlation between IL-10 and proinflammatory markers.
The G allele and GG genotype of IL-6 -174 G/C polymorphism were more frequently noticed in NASH patients.
Regarding IL-10 -1082 G/A polymorphism, the AA genotype was correlated with NASH and with a low plasmatic level of IL-10.
The A allele in position 308 of the TNF-α gene was associated with high level of cytokine.
In conclusion, there was an imbalance between pro- and anti-inflammatory cytokines in NASH patients.
IL-10 -1082 G/A and TNF-α -308 G/A genotypes were correlated with the plasmatic levels of cytokines.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bocsan, Ioana Corina& Milaciu, Mircea Vasile& Pop, Raluca Maria& Vesa, Stefan Cristian& Ciumarnean, Lorena& Matei, Daniela Maria…[et al.]. 2017. Cytokines Genotype-Phenotype Correlation in Nonalcoholic Steatohepatitis. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1194681
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bocsan, Ioana Corina…[et al.]. Cytokines Genotype-Phenotype Correlation in Nonalcoholic Steatohepatitis. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1194681
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bocsan, Ioana Corina& Milaciu, Mircea Vasile& Pop, Raluca Maria& Vesa, Stefan Cristian& Ciumarnean, Lorena& Matei, Daniela Maria…[et al.]. Cytokines Genotype-Phenotype Correlation in Nonalcoholic Steatohepatitis. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1194681
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194681
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر