Age and Environment Influences on Mouse Prion Disease Progression: Behavioral Changes and Morphometry and Stereology of Hippocampal Astrocytes
المؤلفون المشاركون
Bento-Torres, João
Picanço-Diniz, Cristovam Wanderley
Vasconcelos, Pedro F. C.
Anthony, Daniel C.
Reis, R. R.
de Oliveira, R. B.
Sobral, Luciane Lobato
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-24
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Because enriched environment (EE) and exercise increase and aging decreases immune response, we hypothesized that environmental enrichment and aging will, respectively, delay and increase prion disease progression.
Mice dorsal striatum received bilateral stereotaxic intracerebral injections of normal or ME7 prion infected mouse brain homogenates.
After behavior analysis, animals were euthanized and their brains processed for astrocyte GFAP immunolabeling.
Our analysis related to the environmental influence are limited to young adult mice, whereas age influence refers to aged mice raised on standard cages.
Burrowing activity began to reduce in ME7-SE two weeks before ME7-EE, while no changes were apparent in ME7 aged mice (ME7-A).
Object placement recognition was impaired in ME7-SE, NBH-A, and ME7-A but normal in all other groups.
Object identity recognition was impaired in ME7-A.
Cluster analysis revealed two morphological families of astrocytes in NBH-SE animals, three in NBH-A and ME7-A, and four in NBH-EE, ME7-SE, and ME7-EE.
As compared with control groups, astrocytes from DG and CA3 prion-diseased animals show significant numerical and morphological differences and environmental enrichment did not reverse these changes but induced different morphological changes in GFAP+ hippocampal astroglia.
We suggest that environmental enrichment and aging delayed hippocampal-dependent behavioral and neuropathological signs of disease progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bento-Torres, João& Sobral, Luciane Lobato& Reis, R. R.& de Oliveira, R. B.& Anthony, Daniel C.& Vasconcelos, Pedro F. C.…[et al.]. 2017. Age and Environment Influences on Mouse Prion Disease Progression: Behavioral Changes and Morphometry and Stereology of Hippocampal Astrocytes. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1194722
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bento-Torres, João…[et al.]. Age and Environment Influences on Mouse Prion Disease Progression: Behavioral Changes and Morphometry and Stereology of Hippocampal Astrocytes. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1194722
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bento-Torres, João& Sobral, Luciane Lobato& Reis, R. R.& de Oliveira, R. B.& Anthony, Daniel C.& Vasconcelos, Pedro F. C.…[et al.]. Age and Environment Influences on Mouse Prion Disease Progression: Behavioral Changes and Morphometry and Stereology of Hippocampal Astrocytes. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1194722
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194722
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر