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Rutin as a Mediator of Lipid Metabolism and Cellular Signaling Pathways Interactions in Fibroblasts Altered by UVA and UVB Radiation
المؤلفون المشاركون
Gęgotek, Agnieszka
Rybałtowska-Kawałko, Paula
Skrzydlewska, Elżbieta
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-12
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
Background.
Rutin is a natural nutraceutical that is a promising compound for the prevention of UV-induced metabolic changes in skin cells.
The aim of this study was to examine the effects of rutin on redox and endocannabinoid systems, as well as proinflammatory and proapoptotic processes, in UV-irradiated fibroblasts.
Methods.
Fibroblasts exposed to UVA and UVB radiation were treated with rutin.
The activities and levels of oxidants/antioxidants and endocannabinoid system components, as well as lipid, DNA, and protein oxidation products, and the proinflammatory and pro/antiapoptotic proteins expression were measured.
Results.
Rutin reduced UV-induced proinflammatory response and ROS generation and enhanced the activity/levels of antioxidants (SOD, GSH-Px, vitamin E, GSH, and Trx).
Rutin also normalized UV-induced Nrf2 expression.
Its biological activity prevented changes in the levels of the lipid mediators: MDA, 4-HNE, and endocannabinoids, as well as the endocannabinoid receptors CB1/2, VR1, and GPR55 expression.
Furthermore, rutin prevented the protein modifications (tyrosine derivatives formation in particular) and decreased the levels of the proapoptotic markers—caspase-3 and cytochrome c.
Conclusion.
Rutin prevents UV-induced inflammation and redox imbalance at protein and transcriptional level which favors lipid, protein, and DNA protection.
In consequence rutin regulates endocannabinoid system and apoptotic balance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gęgotek, Agnieszka& Rybałtowska-Kawałko, Paula& Skrzydlewska, Elżbieta. 2017. Rutin as a Mediator of Lipid Metabolism and Cellular Signaling Pathways Interactions in Fibroblasts Altered by UVA and UVB Radiation. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-20.
https://search.emarefa.net/detail/BIM-1194792
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gęgotek, Agnieszka…[et al.]. Rutin as a Mediator of Lipid Metabolism and Cellular Signaling Pathways Interactions in Fibroblasts Altered by UVA and UVB Radiation. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-20.
https://search.emarefa.net/detail/BIM-1194792
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gęgotek, Agnieszka& Rybałtowska-Kawałko, Paula& Skrzydlewska, Elżbieta. Rutin as a Mediator of Lipid Metabolism and Cellular Signaling Pathways Interactions in Fibroblasts Altered by UVA and UVB Radiation. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-20.
https://search.emarefa.net/detail/BIM-1194792
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194792
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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