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Neuroprotection of Catalpol for Experimental Acute Focal Ischemic Stroke: Preclinical Evidence and Possible Mechanisms of Antioxidation, Anti-Inflammation, and Antiapoptosis
المؤلفون المشاركون
Zheng, Xia-wei
Yang, Wen-ting
Chen, Shuang
Xu, Qing-qing
Shan, Chun-shuo
Ruan, Ji-chen
Zheng, Guo-qing
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-24، 24ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-13
دولة النشر
مصر
عدد الصفحات
24
التخصصات الرئيسية
الملخص EN
Neuroprotection is defined as using a therapy that affects the brain tissue in the still-viable ischemic penumbra to salvage or delay the infarction.
Catalpol, the main active principle of the root of Radix Rehmanniae, was reported to have pleiotropic neuroprotective effects in neurodegenerative diseases including ischemic stroke.
Here, we evaluated the neuroprotective effects of catalpol in experimental acute ischemic stroke.
Studies on catalpol in animal models of acute ischemic stroke were identified from 6 databases.
Twenty-five studies involving 805 animals were included.
Twelve comparisons showed significant effects of catalpol on decreasing infarct size according to 2,3,5-triphenyltetrazolium chloride staining compared with the control (P<0.05).
One study reported significant effect of catalpol on reducing infarct size according to magnetic resonance imaging scan compared with the control (P<0.05).
Meta-analysis of these studies indicated that catalpol significantly improved the neurological function score according to Zea Longa score, Bederson score, balance beam-walking test, adhesive removal test, bar-grasping score, and corner test compared with the control (P<0.05).
In conclusion, catalpol exerted neuroprotective effects for experimental acute focal ischemic stroke, largely through reducing oxidative reactions, inhibiting apoptosis, and repressing inflammatory reactions and autophagy.
However, these apparently positive findings should be interpreted with caution because of the methodological flaws.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zheng, Xia-wei& Yang, Wen-ting& Chen, Shuang& Xu, Qing-qing& Shan, Chun-shuo& Zheng, Guo-qing…[et al.]. 2017. Neuroprotection of Catalpol for Experimental Acute Focal Ischemic Stroke: Preclinical Evidence and Possible Mechanisms of Antioxidation, Anti-Inflammation, and Antiapoptosis. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-24.
https://search.emarefa.net/detail/BIM-1194849
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zheng, Xia-wei…[et al.]. Neuroprotection of Catalpol for Experimental Acute Focal Ischemic Stroke: Preclinical Evidence and Possible Mechanisms of Antioxidation, Anti-Inflammation, and Antiapoptosis. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-24.
https://search.emarefa.net/detail/BIM-1194849
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zheng, Xia-wei& Yang, Wen-ting& Chen, Shuang& Xu, Qing-qing& Shan, Chun-shuo& Zheng, Guo-qing…[et al.]. Neuroprotection of Catalpol for Experimental Acute Focal Ischemic Stroke: Preclinical Evidence and Possible Mechanisms of Antioxidation, Anti-Inflammation, and Antiapoptosis. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-24.
https://search.emarefa.net/detail/BIM-1194849
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194849
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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