Preclinical Antileukemia Activity of Tramesan: A Newly Identified Bioactive Fungal Metabolite
المؤلفون المشاركون
Ricciardi, M. R.
Licchetta, R.
Mirabilii, S.
Scarpari, M.
Parroni, A.
Fabbri, A. A.
Cescutti, P.
Reverberi, M.
Fanelli, C.
Tafuri, A.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Despite improvements that occurred in the last decades in the acute myeloid leukemia (AML) treatment, clinical results are still unsatisfactory.
More effective therapies are required, and innovative approaches are ongoing, including the discovery of novel antileukemia natural compounds.
Several studies have described the activity of extracts from mushrooms which produce compounds that exhibited immunological and antitumor activities.
The latter has been demonstrated to be promoted in vitro by mushroom polysaccharides via induction of apoptosis.
However, the antileukemia activity of these compounds on primary cells is still not reported.
In the present study, we examined the in vitro effects of Tramesan (TR), a bioactive compound extracted from Trametes versicolor, on leukemic cell lines and primary cells.
Our results demonstrated that TR induced a marked growth inhibition of leukemic cell lines and primary cells from AML patients.
The antiproliferative effects of TR were associated in primary AML cells with a significant increase of apoptosis.
No significant cytotoxic effects were observed in normal peripheral blood mononuclear cells (MNC) from healthy donors.
Our data demonstrated a cytotoxic activity of TR on leukemia cells prompting further translational applications.
Ongoing studies are elucidating the molecular mechanisms underlying its antileukemic activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ricciardi, M. R.& Licchetta, R.& Mirabilii, S.& Scarpari, M.& Parroni, A.& Fabbri, A. A.…[et al.]. 2017. Preclinical Antileukemia Activity of Tramesan: A Newly Identified Bioactive Fungal Metabolite. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1194853
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ricciardi, M. R.…[et al.]. Preclinical Antileukemia Activity of Tramesan: A Newly Identified Bioactive Fungal Metabolite. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1194853
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ricciardi, M. R.& Licchetta, R.& Mirabilii, S.& Scarpari, M.& Parroni, A.& Fabbri, A. A.…[et al.]. Preclinical Antileukemia Activity of Tramesan: A Newly Identified Bioactive Fungal Metabolite. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1194853
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194853
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر