Preparation and Evaluation of Doxorubicin-Loaded Micelles Based on Glycyrrhetinic Acid Modified Gelatin Conjugates for Targeting Hepatocellular Carcinoma
المؤلفون المشاركون
Yu, Jingmou
Xu, Xiao
Fan, Dun
Yan, Ruiqiao
Wang, Yunfei
Xie, Xin
Liu, Chaolian
Liu, Yonghua
Huang, Hao
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-01-01
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Hepatocellular carcinoma (HCC) is one of the most prevalent fatal diseases and the incidence of HCC is increasing worldwide.
Polymeric micelles with targeting groups have drawn great attention as carriers for drug delivery in HCC therapy.
Herein, novel glycyrrhetinic acid modified gelatin (GA-GEL) conjugates with three substitution degrees were synthesized and characterized.
Doxorubicin (DOX) was applied as a model drug.
DOX-loaded GA-GEL (DOX/GA-GEL) micelles were prepared by an emulsion-solvent evaporation method.
The mean diameters of DOX/GA-GEL micelles were in the range of 195–235 nm.
The encapsulation efficiency of DOX/GA-GEL micelles was 63.6%–96.2%, and the loading content was 8.3%–12.5%.
Drug release from DOX-loaded micelles exhibited a biphasic manner in phosphate buffer solution (PBS) at pH 7.4.
DOX/GA-GEL could be efficiently accumulated into human liver cancer HepG2 cells.
The IC50 values of DOX/GA-GEL-2 and DOX·HCl in HepG2 cells were 0.33 and 0.66 μg/mL, respectively.
In vivo imaging analysis demonstrated that the fluorescence signals of DiR-labeled GA-GEL-2 micelles were mainly distributed in liver and H22 orthotopic tumor, indicating that GA-GEL had the liver-targeting activity.
Compared to DOX·HCl, DOX/GA-GEL-2 exhibited better antitumor activity in H22 orthotopic mice.
Therefore, these results indicated that GA-GEL could be used as carrier of hydrophobic drug for targeting HCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fan, Dun& Yu, Jingmou& Yan, Ruiqiao& Xu, Xiao& Wang, Yunfei& Xie, Xin…[et al.]. 2018. Preparation and Evaluation of Doxorubicin-Loaded Micelles Based on Glycyrrhetinic Acid Modified Gelatin Conjugates for Targeting Hepatocellular Carcinoma. Journal of Nanomaterials،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1194911
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fan, Dun…[et al.]. Preparation and Evaluation of Doxorubicin-Loaded Micelles Based on Glycyrrhetinic Acid Modified Gelatin Conjugates for Targeting Hepatocellular Carcinoma. Journal of Nanomaterials No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1194911
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fan, Dun& Yu, Jingmou& Yan, Ruiqiao& Xu, Xiao& Wang, Yunfei& Xie, Xin…[et al.]. Preparation and Evaluation of Doxorubicin-Loaded Micelles Based on Glycyrrhetinic Acid Modified Gelatin Conjugates for Targeting Hepatocellular Carcinoma. Journal of Nanomaterials. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1194911
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194911
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر