Identification of Four Oxidative Stress-Responsive MicroRNAs, miR-34a-5p, miR-1915-3p, miR-638, and miR-150-3p, in Hepatocellular Carcinoma
المؤلفون المشاركون
Zhang, Xinhua
Liu, Chang
Wan, Yong
Cui, Ruixia
Gu, Jingxian
Xiang, Xiaohong
Qu, Kai
Lin, Ting
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-24
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Increasing evidence suggests that oxidative stress plays an essential role during carcinogenesis.
However, the underlying mechanism between oxidative stress and carcinogenesis remains unknown.
Recently, microRNAs (miRNAs) are revealed to be involved in oxidative stress response and carcinogenesis.
This study aims to identify miRNAs in hepatocellular carcinoma (HCC) cells which might involve in oxidative stress response.
An integrated analysis of miRNA expression signature was performed by employing robust rank aggregation (RRA) method, and four miRNAs (miR-34a-5p, miR-1915-3p, miR-638, and miR-150-3p) were identified as the oxidative stress-responsive miRNAs.
Pathway enrichment analysis suggested that these four miRNAs played an important role in antiapoptosis process.
Our data also revealed miR-34a-5p and miR-1915-3p, but not miR-150-3p and miR-638, were regulated by p53 in HCC cell lines under oxidative stress.
In addition, clinical investigation revealed that these four miRNAs might be involved in oxidative stress response by targeting oxidative stress-related genes in HCC tissues.
Kaplan-Meier analysis showed that these four miRNAs were associated with patients’ overall survival.
In conclusion, we identified four oxidative stress-responsive miRNAs, which were regulated by p53-dependent (miR-34a-5p and miR-1915-3p) and p53-independent pathway (miR-150-3p and miR-638).
These four miRNAs may offer new strategy for HCC diagnosis and prognosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wan, Yong& Cui, Ruixia& Gu, Jingxian& Zhang, Xinhua& Xiang, Xiaohong& Liu, Chang…[et al.]. 2017. Identification of Four Oxidative Stress-Responsive MicroRNAs, miR-34a-5p, miR-1915-3p, miR-638, and miR-150-3p, in Hepatocellular Carcinoma. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194919
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wan, Yong…[et al.]. Identification of Four Oxidative Stress-Responsive MicroRNAs, miR-34a-5p, miR-1915-3p, miR-638, and miR-150-3p, in Hepatocellular Carcinoma. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1194919
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wan, Yong& Cui, Ruixia& Gu, Jingxian& Zhang, Xinhua& Xiang, Xiaohong& Liu, Chang…[et al.]. Identification of Four Oxidative Stress-Responsive MicroRNAs, miR-34a-5p, miR-1915-3p, miR-638, and miR-150-3p, in Hepatocellular Carcinoma. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1194919
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194919
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر