Depletion of the Third Complement Component Ameliorates Age-Dependent Oxidative Stress and Positively Modulates Autophagic Activity in Aged Retinas in a Mouse Model
المؤلفون المشاركون
Wiszniewska, Barbara
Machalinska, Anna
Roginska, Dorota
Machalinski, Boguslaw
Pius-Sadowska, Ewa
Kawa, Miłosz P.
Lejkowska, Renata
Schmidt, Christian A.
Łuczkowska, Karolina
Paterno, Jussi J.
Kaarniranta, Kai
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-08
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
The aim of the study was to investigate the influence of complement component C3 global depletion on the biological structure and function of the aged retina.
In vivo morphology (OCT), electrophysiological function (ERG), and the expression of selected oxidative stress-, apoptosis-, and autophagy-related proteins were assessed in retinas of 12-month-old C3-deficient and WT mice.
Moreover, global gene expression in retinas was analyzed by RNA arrays.
We found that the absence of active C3 was associated with (1) alleviation of the age-dependent decrease in retinal thickness and gradual deterioration of retinal bioelectrical function, (2) significantly higher levels of antioxidant enzymes (catalase and glutathione reductase) and the antiapoptotic survivin and Mcl-1/Bak dimer, (3) lower expression of the cellular oxidative stress marker—4HNE—and decreased activity of proapoptotic caspase-3, (4) ameliorated retinal autophagic activity with localization of ubiquitinated protein conjugates commonly along the retinal pigment epithelium (RPE) layer, and (5) significantly increased expression of several gene sets associated with maintenance of the physiological functions of the neural retina.
Our findings shed light on mechanisms of age-related retinal alterations by identifying C3 as a potential therapeutic target for retinal aging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Roginska, Dorota& Kawa, Miłosz P.& Pius-Sadowska, Ewa& Lejkowska, Renata& Łuczkowska, Karolina& Wiszniewska, Barbara…[et al.]. 2017. Depletion of the Third Complement Component Ameliorates Age-Dependent Oxidative Stress and Positively Modulates Autophagic Activity in Aged Retinas in a Mouse Model. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1194943
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Roginska, Dorota…[et al.]. Depletion of the Third Complement Component Ameliorates Age-Dependent Oxidative Stress and Positively Modulates Autophagic Activity in Aged Retinas in a Mouse Model. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-17.
https://search.emarefa.net/detail/BIM-1194943
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Roginska, Dorota& Kawa, Miłosz P.& Pius-Sadowska, Ewa& Lejkowska, Renata& Łuczkowska, Karolina& Wiszniewska, Barbara…[et al.]. Depletion of the Third Complement Component Ameliorates Age-Dependent Oxidative Stress and Positively Modulates Autophagic Activity in Aged Retinas in a Mouse Model. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-17.
https://search.emarefa.net/detail/BIM-1194943
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1194943
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر