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Impact on Autophagy and Ultraviolet B Induced Responses of Treatment with the MTOR Inhibitors Rapamycin, Everolimus, Torin 1, and pp242 in Human Keratinocytes
المؤلفون المشاركون
Ju, Mei
Gu, Heng
Xu, Song
Li, Li
Li, Min
Zhang, Mengli
Chen, Xu
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-16
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
The mechanistic target of Rapamycin (MTOR) protein is a crucial signaling regulator in mammalian cells that is extensively involved in cellular biology.
The function of MTOR signaling in keratinocytes remains unclear.
In this study, we detected the MTOR signaling and autophagy response in the human keratinocyte cell line HaCaT and human epidermal keratinocytes treated with MTOR inhibitors.
Moreover, we detected the impact of MTOR inhibitors on keratinocytes exposed to the common carcinogenic stressors ultraviolet B (UVB) and UVA radiation.
As a result, keratinocytes were sensitive to the MTOR inhibitors Rapamycin, everolimus, Torin 1, and pp242, but the regulation of MTOR downstream signaling was distinct.
Next, autophagy induction only was observed in HaCaT cells treated with Rapamycin.
Furthermore, we found that MTOR signaling was insensitive to UVB but sensitive to UVA radiation.
UVB treatment also had no impact on the inhibition of MTOR signaling by MTOR inhibitors.
Finally, MTOR inhibition by Rapamycin, everolimus, or pp242 did not affect the series of biological events in keratinocytes exposed to UVB, including the downregulation of BiP and PERK, activation of Histone H2A and JNK, and cleavage of caspase-3 and PARP.
Our study demonstrated that MTOR inhibition in keratinocytes cannot always induce autophagy, and the MTOR pathway does not play a central role in the UVB triggered cellular response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Song& Li, Li& Li, Min& Zhang, Mengli& Ju, Mei& Chen, Xu…[et al.]. 2017. Impact on Autophagy and Ultraviolet B Induced Responses of Treatment with the MTOR Inhibitors Rapamycin, Everolimus, Torin 1, and pp242 in Human Keratinocytes. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-21.
https://search.emarefa.net/detail/BIM-1195096
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Song…[et al.]. Impact on Autophagy and Ultraviolet B Induced Responses of Treatment with the MTOR Inhibitors Rapamycin, Everolimus, Torin 1, and pp242 in Human Keratinocytes. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-21.
https://search.emarefa.net/detail/BIM-1195096
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Song& Li, Li& Li, Min& Zhang, Mengli& Ju, Mei& Chen, Xu…[et al.]. Impact on Autophagy and Ultraviolet B Induced Responses of Treatment with the MTOR Inhibitors Rapamycin, Everolimus, Torin 1, and pp242 in Human Keratinocytes. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-21.
https://search.emarefa.net/detail/BIM-1195096
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195096
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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