![](/images/graphics-bg.png)
Mitochondria-Targeted Antioxidant SkQ1 Improves Dermal Wound Healing in Genetically Diabetic Mice
المؤلفون المشاركون
Skulachev, Vladimir P.
Manskikh, Vasily N.
Zinovkin, Roman A.
Demyanenko, Ilya A.
Zakharova, Vlada V.
Ilyinskaya, Olga P.
Vasilieva, Tamara V.
Fedorov, Artem V.
Pletjushkina, Olga Yu
Chernyak, Boris V.
Popova, Ekaterina N.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-06
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Oxidative stress is widely recognized as an important factor in the delayed wound healing in diabetes.
However, the role of mitochondrial reactive oxygen species in this process is unknown.
It was assumed that mitochondrial reactive oxygen species are involved in many wound-healing processes in both diabetic humans and animals.
We have applied the mitochondria-targeted antioxidant 10-(6′-plastoquinonyl)decyltriphenylphosphonium (SkQ1) to explore the role of mitochondrial reactive oxygen species in the wound healing of genetically diabetic mice.
Healing of full-thickness excisional dermal wounds in diabetic C57BL/KsJ-db−/db− mice was significantly enhanced after long-term (12 weeks) administration of SkQ1.
SkQ1 accelerated wound closure and stimulated epithelization, granulation tissue formation, and vascularization.
On the 7th day after wounding, SkQ1 treatment increased the number of α-smooth muscle actin-positive cells (myofibroblasts), reduced the number of neutrophils, and increased macrophage infiltration.
SkQ1 lowered lipid peroxidation level but did not change the level of the circulatory IL-6 and TNF.
SkQ1 pretreatment also stimulated cell migration in a scratch-wound assay in vitro under hyperglycemic condition.
Thus, a mitochondria-targeted antioxidant normalized both inflammatory and regenerative phases of wound healing in diabetic mice.
Our results pointed to nearly all the major steps of wound healing as the target of excessive mitochondrial reactive oxygen species production in type II diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Demyanenko, Ilya A.& Zakharova, Vlada V.& Ilyinskaya, Olga P.& Vasilieva, Tamara V.& Fedorov, Artem V.& Manskikh, Vasily N.…[et al.]. 2017. Mitochondria-Targeted Antioxidant SkQ1 Improves Dermal Wound Healing in Genetically Diabetic Mice. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1195236
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Demyanenko, Ilya A.…[et al.]. Mitochondria-Targeted Antioxidant SkQ1 Improves Dermal Wound Healing in Genetically Diabetic Mice. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1195236
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Demyanenko, Ilya A.& Zakharova, Vlada V.& Ilyinskaya, Olga P.& Vasilieva, Tamara V.& Fedorov, Artem V.& Manskikh, Vasily N.…[et al.]. Mitochondria-Targeted Antioxidant SkQ1 Improves Dermal Wound Healing in Genetically Diabetic Mice. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1195236
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195236
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)