Salusin-β Is Involved in Diabetes Mellitus-Induced Endothelial Dysfunction via Degradation of Peroxisome Proliferator-Activated Receptor Gamma
المؤلفون المشاركون
Sun, Hai-Jian
Chen, Dan
Wang, Pei-Yao
Wan, Ming-Yu
Zhang, Chen-Xing
Zhang, Zhi-Xuan
Lin, Wei
Zhang, Feng
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-19
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The pathophysiological mechanisms for vascular lesions in diabetes mellitus (DM) are complex, among which endothelial dysfunction plays a vital role.
Therapeutic target against endothelial injury may provide critical venues for treatment of diabetic vascular diseases.
We recently identified that salusin-β contributed to high glucose-induced endothelial cell apoptosis.
However, the roles of salusin-β in DM-induced endothelial dysfunction remain largely elusive.
Male C57BL/6J mice were used to induce type 2 diabetes mellitus (T2DM) model.
Human umbilical vein endothelial cells (HUVECs) were cultured in high glucose/high fat (HG/HF) medium.
We demonstrated increased expression of salusin-β in diabetic aortic tissues and high-glucose/high-fat- (HG/HF-) incubated HUVECs.
Disruption of salusin-β by shRNA abrogated the reactive oxygen species (ROS) production, inflammation, and nitrotyrosine content of HUVECs cultured in HG/HF medium.
The HG/HF-mediated decrease in peroxisome proliferator-activated receptor γ (PPARγ) expression was restored by salusin-β shRNA, and PPARγ inhibitor T0070907 abolished the protective actions of salusin-β shRNA on endothelial injury in HG/HF-treated HUVECs.
Salusin-β silencing obviously improved endothelium-dependent vasorelaxation, oxidative stress, inflammatory response, and nitrative stress in diabetic aorta.
Taken together, our results highlighted the essential role of salusin-β in pathological endothelial dysfunction, and salusin-β may be a promising target in treatment of vascular complications of DM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Hai-Jian& Chen, Dan& Wang, Pei-Yao& Wan, Ming-Yu& Zhang, Chen-Xing& Zhang, Zhi-Xuan…[et al.]. 2017. Salusin-β Is Involved in Diabetes Mellitus-Induced Endothelial Dysfunction via Degradation of Peroxisome Proliferator-Activated Receptor Gamma. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1195347
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Hai-Jian…[et al.]. Salusin-β Is Involved in Diabetes Mellitus-Induced Endothelial Dysfunction via Degradation of Peroxisome Proliferator-Activated Receptor Gamma. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1195347
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Hai-Jian& Chen, Dan& Wang, Pei-Yao& Wan, Ming-Yu& Zhang, Chen-Xing& Zhang, Zhi-Xuan…[et al.]. Salusin-β Is Involved in Diabetes Mellitus-Induced Endothelial Dysfunction via Degradation of Peroxisome Proliferator-Activated Receptor Gamma. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1195347
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195347
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر