Role of Mitochondrial Genome Mutations in Pathogenesis of Carotid Atherosclerosis
المؤلفون المشاركون
Sazonova, Margarita A.
Sinyov, Vasily V.
Ryzhkova, Anastasia I.
Galitsyna, Elena V.
Khasanova, Zukhra B.
Yarygina, Elena I.
Postnov, Anton Y.
Orekhov, Alexander N.
Sobenin, Igor A.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Mutations of mtDNA, due to their higher frequency of occurrence compared to nuclear DNA mutations, are the most promising biomarkers for assessing predisposition of the occurrence and development of atherogenesis.
The aim of the present article was an analysis of correlation of several mitochondrial genome mutations with carotid atherosclerosis.
Leukocytes from blood of study participants from Moscow polyclinics were used as research material.
The sample size was 700 people.
The sample members were diagnosed with “atherosclerosis” on the basis of ultrasonographic examination and biochemical and molecular cell tests.
DNA was isolated from blood leukocyte samples of the study participants.
PCR fragments of DNA, containing the region of 11 investigated mutations, were pyrosequenced.
The heteroplasmy level of these mutations was detected.
Statistical analysis of the obtained results was performed using the software package SPSS 22.0.
According to the obtained results, an association of mutations m.652delG, m.3336C>T, m.12315G>A, m.14459G>A m.15059G>A with carotid atherosclerosis was found.
These mutations can be biomarkers for assessing predisposition to this disease.
Additionally, two single nucleotide substitutions (m.13513G>A and m.14846G>A), negatively correlating with atherosclerotic lesions, were detected.
These mutations may be potential candidates for gene therapy of atherosclerosis and its risk factors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sazonova, Margarita A.& Sinyov, Vasily V.& Ryzhkova, Anastasia I.& Galitsyna, Elena V.& Khasanova, Zukhra B.& Postnov, Anton Y.…[et al.]. 2017. Role of Mitochondrial Genome Mutations in Pathogenesis of Carotid Atherosclerosis. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1195361
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sazonova, Margarita A.…[et al.]. Role of Mitochondrial Genome Mutations in Pathogenesis of Carotid Atherosclerosis. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1195361
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sazonova, Margarita A.& Sinyov, Vasily V.& Ryzhkova, Anastasia I.& Galitsyna, Elena V.& Khasanova, Zukhra B.& Postnov, Anton Y.…[et al.]. Role of Mitochondrial Genome Mutations in Pathogenesis of Carotid Atherosclerosis. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1195361
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195361
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر