Possible Mechanisms of Mercury Toxicity and Cancer Promotion: Involvement of Gap Junction Intercellular Communications and Inflammatory Cytokines
المؤلفون المشاركون
Zefferino, Roberto
Piccoli, Claudia
Ricciardi, Nunzia
Scrima, Rosella
Capitanio, Nazzareno
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-21
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
A number of observations indicate that heavy metals are able to alter cellular metabolic pathways through induction of a prooxidative state.
Nevertheless, the outcome of heavy metal-mediated effects in the development of human diseases is debated and needs further insights.
Cancer is a well-established DNA mutation-linked disease; however, epigenetic events are perhaps more important and harmful than genetic alterations.
Unfortunately, we do not have reliable screening methods to assess/validate the epigenetic (promoter) effects of a physical or a chemical agent.
We propose a mechanism of action whereby mercury acts as a possible promoter carcinogen.
In the present contribution, we resume our previous studies on mercury tested at concentrations comparable with its occurrence as environmental pollutant.
It is shown that Hg(II) elicits a prooxidative state in keratinocytes linked to inhibition of gap junction-mediated intercellular communication and proinflammatory cytokine production.
These combined effects may on one hand isolate cells from tissue-specific homeostasis promoting their proliferation and on the other hand tamper the immune system defense/surveillance checkmating the whole organism.
Since Hg(II) is not a mutagenic/genotoxic compound directly affecting gene expression, in a broader sense, mercury might be an example of an epigenetic tumor promoter or, further expanding this concept, a “metagenetic” effector.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zefferino, Roberto& Piccoli, Claudia& Ricciardi, Nunzia& Scrima, Rosella& Capitanio, Nazzareno. 2017. Possible Mechanisms of Mercury Toxicity and Cancer Promotion: Involvement of Gap Junction Intercellular Communications and Inflammatory Cytokines. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1195397
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zefferino, Roberto…[et al.]. Possible Mechanisms of Mercury Toxicity and Cancer Promotion: Involvement of Gap Junction Intercellular Communications and Inflammatory Cytokines. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1195397
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zefferino, Roberto& Piccoli, Claudia& Ricciardi, Nunzia& Scrima, Rosella& Capitanio, Nazzareno. Possible Mechanisms of Mercury Toxicity and Cancer Promotion: Involvement of Gap Junction Intercellular Communications and Inflammatory Cytokines. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1195397
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195397
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر