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Chronic Variable Stress Is Responsible for Lipid and DNA Oxidative Disorders and Activation of Oxidative Stress Response Genes in the Brain of Rats
المؤلفون المشاركون
Wrobel, Andrzej
Herbet, Mariola
Izdebska, Magdalena
Gawrońska-Grzywacz, Monika
Dudka, Jarosław
Korga, Agnieszka
Piątkowska-Chmiel, Iwona
Poleszak, Ewa
Matysiak, Włodzimierz
Jodłowska-Jędrych, Barbara
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Chronic environmental stress is associated with reactive oxygen species (ROS) overproduction and the pathogenesis of depression.
The purpose of this study was to evaluate biochemical and molecular changes associated with ROS generation in the brains of rats submitted to chronic variable stress.
Male Wistar rats (50–55 days old, weighing 200–250 g) were divided in two groups (n=10): control and stressed.
Rats in the stressed group were exposed to stress conditions for 40 days.
The animals were decapitated and the brain samples were collected.
In prefrontal cortex, we measured the following biochemical parameters: lipid peroxidation and concentration of glutathione—GSH, GSSG, GSH/GSSG ratio, glutathione peroxidase, and glutathione reductase activities.
In the hippocampus marker of DNA, oxidative damage and expression of DNA-repairing genes (Ogg1, MsrA) and gene-encoding antioxidative transcriptional factor (Nrf2) were determined.
The results demonstrate indirect evidence of ROS overproduction and presence of oxidative stress.
They also reveal disruption of oxidative defense systems (decreased GR activity, diminished GSH/GSSG ratio, and decreased Nrf2 expression) and activation of the oxidative DNA repair system (increased Ogg1 and MsrA expression).
Together, the presented data suggest that independent activation of oxidative stress response genes occurs in chronic variable stress conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Herbet, Mariola& Korga, Agnieszka& Gawrońska-Grzywacz, Monika& Izdebska, Magdalena& Piątkowska-Chmiel, Iwona& Poleszak, Ewa…[et al.]. 2017. Chronic Variable Stress Is Responsible for Lipid and DNA Oxidative Disorders and Activation of Oxidative Stress Response Genes in the Brain of Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1195589
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Herbet, Mariola…[et al.]. Chronic Variable Stress Is Responsible for Lipid and DNA Oxidative Disorders and Activation of Oxidative Stress Response Genes in the Brain of Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1195589
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Herbet, Mariola& Korga, Agnieszka& Gawrońska-Grzywacz, Monika& Izdebska, Magdalena& Piątkowska-Chmiel, Iwona& Poleszak, Ewa…[et al.]. Chronic Variable Stress Is Responsible for Lipid and DNA Oxidative Disorders and Activation of Oxidative Stress Response Genes in the Brain of Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1195589
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195589
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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