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Improvement of Stability and Transdermal Delivery of Bioactive Compounds in Green Robusta Coffee Beans Extract Loaded Nanostructured Lipid Carriers
المؤلفون المشاركون
Natakankitkul, Surapol
Viernstein, H.
Nitthikan, Nichcha
Leelapornpisid, Pimporn
Chaiyana, Wantida
Mueller, Monika
Kiattisin, Kanokwan
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-10
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The aim of this study was to develop green robusta coffee beans extract loaded nanostructured lipid carriers (NLCs) for enhancing dermal application and its efficiency.
The green robusta coffee beans extract cultivated in Chumphon (CP) exhibited the highest antioxidant activity in the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay with IC50 of 34.1 ± 0.9 µg/ml, lipid peroxidation inhibition with percentage inhibition of 38.8 ± 1.7, and ferric reducing antioxidant power (FRAP) assay with a FRAP value of 234.5 ± 12.3 mM FeSO4/g.
The extract contained caffeine, chlorogenic acid, and caffeic acid as major compounds.
The anti-inflammatory test indicated that CP could decrease the secretion of IL-6 in macrophage cells and caused no irritation to blood vessels on the irritation test by hen’s egg test chorioallantoic membrane (HET-CAM) assay.
The particle size of CP-loaded NLCs was 158.1 ± 0.2 nm with a narrow polydispersity index and showed no noticeable difference after the stability test.
Entrapment efficacy of CP-loaded NLCs was found to be over 60%.
Caffeine and chlorogenic acid in CP-loaded NLCs were released sustainably and penetrated deeper into the skin than the extract in a conventional emulsion.
In conclusion, the CP-loaded NLCs can be further used in cosmetics for dermal applications due to good efficacy and safety.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nitthikan, Nichcha& Leelapornpisid, Pimporn& Natakankitkul, Surapol& Chaiyana, Wantida& Mueller, Monika& Viernstein, H.…[et al.]. 2018. Improvement of Stability and Transdermal Delivery of Bioactive Compounds in Green Robusta Coffee Beans Extract Loaded Nanostructured Lipid Carriers. Journal of Nanotechnology،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1195654
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nitthikan, Nichcha…[et al.]. Improvement of Stability and Transdermal Delivery of Bioactive Compounds in Green Robusta Coffee Beans Extract Loaded Nanostructured Lipid Carriers. Journal of Nanotechnology No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1195654
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nitthikan, Nichcha& Leelapornpisid, Pimporn& Natakankitkul, Surapol& Chaiyana, Wantida& Mueller, Monika& Viernstein, H.…[et al.]. Improvement of Stability and Transdermal Delivery of Bioactive Compounds in Green Robusta Coffee Beans Extract Loaded Nanostructured Lipid Carriers. Journal of Nanotechnology. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1195654
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195654
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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