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Prognostic Factors Predicting Poor Outcome in Cancer Patients with Febrile Neutropenia in the Emergency Department: Usefulness of qSOFA
المؤلفون المشاركون
Paik, Jin Hui
Kim, Ji Hye
Han, Seung Baik
Durey, Areum
Lee, Seung Jae
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background/Aims.
Febrile neutropenia is considered as one of the most important and potentially life-threatening oncologic emergencies, which requires prompt medical assessment and treatment with antibiotics.
This was a single-center retrospective study that investigated the prognostic factors predicting poor outcome in patients with cancer who presented with febrile neutropenia at the emergency department (ED).
Methods.
The medical records of patients diagnosed with febrile neutropenia in the ED from January 2014 to December 2017 were reviewed.
Patients aged >18 years who were diagnosed with a malignancy were included in the analysis.
Febrile neutropenia was defined as an absolute neutrophil count < 1,000/mm3 with a temperature greater than 38°C.
Patients were divided into two groups: those who were admitted at the intensive care unit (ICU) or those who died in the hospital (case group) and those who were admitted at general wards and were discharged (control group).
The two groups were compared to determine the factors associated with poor prognosis.
Results.
We identified 104 patients (25 and 79 from the case and control groups, respectively) with cancer who presented with febrile neutropenia at the ED during the study period.
Lower blood pressure, platelet count, and HCO3- level, higher CRP and creatinine level, and the presence of bacteremia were more commonly observed in the case group than in the control group.
In the multiple logistic regression analysis, the following independent predictors significantly correlated with ICU admission and in-hospital mortality: quick sequential (sepsis-related) organ failure assessment (qSOFA) score (odds ratio [OR]: 4.62; 95% confidence interval [CI]: 1.17–18.22; p=0.285), hemoglobin level (OR: 0.51; 95% CI: 0.33–0.78; p=0.002), total bilirubin level (OR: 7.69; 95% CI: 1.29–45.8; p=0.025), and respiratory tract infection (OR: 29.65; 95% CI: 3.81–230.7; p=0.0012).
Conclusions.
The qSOFA can be a useful bedside tool for patients with cancer who present with febrile neutropenia at the ED.
Moreover, it can help emergency physicians in identifying patients at risk of poor prognosis and in initiating prompt empirical antimicrobial therapy.
Further studies must be conducted to validate the efficacy of the qSOFA in these patients in the ED.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Seung Jae& Kim, Ji Hye& Han, Seung Baik& Paik, Jin Hui& Durey, Areum. 2018. Prognostic Factors Predicting Poor Outcome in Cancer Patients with Febrile Neutropenia in the Emergency Department: Usefulness of qSOFA. Journal of Oncology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1195757
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Seung Jae…[et al.]. Prognostic Factors Predicting Poor Outcome in Cancer Patients with Febrile Neutropenia in the Emergency Department: Usefulness of qSOFA. Journal of Oncology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1195757
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Seung Jae& Kim, Ji Hye& Han, Seung Baik& Paik, Jin Hui& Durey, Areum. Prognostic Factors Predicting Poor Outcome in Cancer Patients with Febrile Neutropenia in the Emergency Department: Usefulness of qSOFA. Journal of Oncology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1195757
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195757
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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