Capecitabine and Temozolomide in Neuroendocrine Tumor of Unknown Primary
المؤلفون المشاركون
Weiss, Heidi
Chauhan, Aman
Farooqui, Zainab
Murray, Le Aundra
War Myint, Zin
Raajasekar, Arun Kumar A.
Evers, B. Mark
Arnold, Susanne
Anthony, Lowell
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-05-07
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Incidence of low grade well-differentiated neuroendocrine tumors (NET) is on the rise.
The North American Neuroendocrine Tumor Society estimates that the United States has more than 150,000 gastroenteropancreatic NET patients.
About 10% of metastatic NETs can be unknown primary, and due to their rarity, dedicated treatment algorithms and regimens are not defined.
Combination of capecitabine and temozolomide (CAPTEM) is one of the systemic treatments used in gastroenteropancreatic NETs.
We explored clinical activity of CAPTEM in NET of unknown primary.
Methods.
Retrospective review of NET of unknown primary managed at the University of Kentucky over the past five years (2012–2016).
Result.
56 patients with NET of unknown primary were identified; 12 patients were treated with CAPTEM.
Median progression-free survival on CAPTEM in grade II and grade III NET of unknown primary was 10.8 and 7 months, respectively.
Six patients showed reduction in metastatic tumor volume at three-month CT scan.
Three patients had stable disease and three patients showed disease progression at the first surveillance scan.
Common side-effects were as follows: four patients developed grade II thrombocytopenia, three patients developed grade I lymphocytopenia, and two patients developed hand foot syndrome (grades I and III).
Six patients developed grade I fatigue.
Conclusion.
CAPTEM should be considered for grades I and II NET of unknown primary, especially in the case of visceral crisis or bulky disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chauhan, Aman& Farooqui, Zainab& Murray, Le Aundra& Weiss, Heidi& War Myint, Zin& Raajasekar, Arun Kumar A.…[et al.]. 2018. Capecitabine and Temozolomide in Neuroendocrine Tumor of Unknown Primary. Journal of Oncology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1195773
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chauhan, Aman…[et al.]. Capecitabine and Temozolomide in Neuroendocrine Tumor of Unknown Primary. Journal of Oncology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1195773
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chauhan, Aman& Farooqui, Zainab& Murray, Le Aundra& Weiss, Heidi& War Myint, Zin& Raajasekar, Arun Kumar A.…[et al.]. Capecitabine and Temozolomide in Neuroendocrine Tumor of Unknown Primary. Journal of Oncology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1195773
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195773
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر