Advancing Parental Age and Risk of Solid Tumors in Children: A Case-Control Study in Peru
المؤلفون المشاركون
Vasquez, Liliana
Maza, Ivan
Oscanoa, Monica
Rios, Ligia
Gerónimo, Jenny
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
The causes of childhood cancer are not well known, but the advanced age of the parents has been suggested as a risk factor for childhood cancer in several observational studies.
In this study, we examine a possible link between parental age and childhood solid tumors.
Methods.
We conducted a hospital-based case-control study (310 cases and 620 controls, matched by age and gender) at Rebagliati Hospital, Lima, Peru.
Odd ratio was used to compare categories of advancing maternal and paternal age with and without adjusting for possible confounding factors were calculated.
Results.
The risk of childhood retinoblastoma was significantly higher among children of mothers aged> 35 years (adjusted OR 1.21; 95% CI, 1.09-6.08) and fathers aged> 35 years (OR 1.17; 1.01-16.33).
A significant trend with increasing mother's age (p = 0.037) and father's age (p = 0.005) was found.
There were more risks to development of non-Hodgkin's lymphoma (p = 0.047) and gonadal germ cell tumors (p = 0.04) for advanced paternal age.
There was a strong protective effect of increasing parity on risk of solid tumors in children (p=0.0015).
Conclusion.
Our results suggest that advanced parental age is associated with the risk for the development of retinoblastoma.
Advanced paternal age increases the risk of non-Hodgkin lymphoma and gonadal germ cell tumor.
The higher the order of birth of the children, the less the chance of developing any neoplasm.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rios, Ligia& Vasquez, Liliana& Oscanoa, Monica& Maza, Ivan& Gerónimo, Jenny. 2018. Advancing Parental Age and Risk of Solid Tumors in Children: A Case-Control Study in Peru. Journal of Oncology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1195783
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rios, Ligia…[et al.]. Advancing Parental Age and Risk of Solid Tumors in Children: A Case-Control Study in Peru. Journal of Oncology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1195783
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rios, Ligia& Vasquez, Liliana& Oscanoa, Monica& Maza, Ivan& Gerónimo, Jenny. Advancing Parental Age and Risk of Solid Tumors in Children: A Case-Control Study in Peru. Journal of Oncology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1195783
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195783
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر