Evaluation of Reirradiation in Locally Advanced Head and Neck Cancers: Toxicity and Early Clinical Outcomes
المؤلفون المشاركون
Bahl, Amit
Oinam, Arun Singh
Elangovan, Arun
Kaur, Satinder
Trivedi, Gaurav
Verma, Roshan
Bhandari, Sudhir
Ghoshal, Sushmita
Panda, Naresh Kumar
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-26
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objectives.
Locoregional recurrence is the predominant pattern of treatment failure in advanced head and neck cancers.
Reirradiation is a useful modality to treat inoperable head and neck cancer patients with recurrent disease.
The aim of the present study was to analyze the treatment toxicity and early clinical outcomes in patients undergoing reirradiation.
Methods.
Twenty patients of head and neck cancers with recurrences or second cancers were evaluated.
Reirradiation was done using simultaneous integrated boost volumetric modulated arc therapy (SIB VMAT), intensity modulated radiotherapy (IMRT), or conventional radiotherapy using 6MV photons.
Dose prescription ranged from 30 to 60 Gy in conventional fractionation.
Results.
Seventeen males and three females were evaluated in this analysis.
The median age of patients under study was 56.5 years.
At time of analysis 8 patients (40%) had a complete response, 7 patients (35%) had progressive disease, and 25% had partial response or stable disease.
Grade III-IV mucositis, dermatitis, xerostomia, dysphagia, and trismus were seen in 20%, 20%, 50%, 35%, and 45% patients, respectively, during retreatment.
Patients receiving a radiotherapy dose less than 45 Gy showed a higher incidence of progressive disease (p=0.01).
The median disease-free survival for patients receiving reirradiation dose of ≥46 Gy was 19±3.3 months (median ± S Error) compared to 8±2.61 months for those with a dose prescription less than 45 Gy (p=0.03).
At 18-month follow-up 26% of patients undergoing reirradiation were disease-free.
Conclusions.
Our results show improved tumor control using a prescription of doses ≥46 Gy in retreatment setting.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bahl, Amit& Oinam, Arun Singh& Elangovan, Arun& Kaur, Satinder& Trivedi, Gaurav& Verma, Roshan…[et al.]. 2018. Evaluation of Reirradiation in Locally Advanced Head and Neck Cancers: Toxicity and Early Clinical Outcomes. Journal of Oncology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1195869
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bahl, Amit…[et al.]. Evaluation of Reirradiation in Locally Advanced Head and Neck Cancers: Toxicity and Early Clinical Outcomes. Journal of Oncology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1195869
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bahl, Amit& Oinam, Arun Singh& Elangovan, Arun& Kaur, Satinder& Trivedi, Gaurav& Verma, Roshan…[et al.]. Evaluation of Reirradiation in Locally Advanced Head and Neck Cancers: Toxicity and Early Clinical Outcomes. Journal of Oncology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1195869
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195869
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر