Smallanthus sonchifolius (Yacon) Flour Improves Visceral Adiposity and Metabolic Parameters in High-Fat-Diet-Fed Rats
المؤلفون المشاركون
Honoré, Stella Maris
Grande, Maria Virginia
Gomez Rojas, Jorge
Sánchez, Sara Serafina
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-28
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Smallanthus sonchifolius (yacon), a native plant of South America, was observed to improve lipid profile in rodents and humans.
This study aimed to investigate the antiobesity properties of yacon roots in a high-fat-diet (HFD) model and the underlying mechanisms.
A total of 30 Wistar male rats were divided into five groups (n=6): the standard chow diet (SD) group was fed a SD; the HFD group was fed a HFD; and the HFD Y340 and HFD Y680 groups were fed a HFD plus yacon flour (340 and 680 mg FOS/kg b.
w./day, respectively).
HFD Y340 and HFD Y680 rats exhibited marked attenuation of weight gain, a decrease in visceral fat pad weight, a restoration of the serum lipid profile and atherogenic index in a dose-dependent manner, being the higher dose more effective (p<0.05).
In addition, we found that HFD Y680 rats showed lower glucose and insulin levels, improved glucose tolerance, and insulin sensitivity (p<0.5).
A downregulation of several adipocyte specific-transcription factors, including peroxisome proliferator-activated receptor gamma2 (PPAR-γ2), CCAAT/enhancer binding protein a (C/EBP-a) and activating protein (aP2) mRNA levels, was determined in the visceral adipose tissue of HFD Y680 rats (p<0.05).
An improvement of adipokine profile in HFD Y680 rats and decreased serum proinflammatory cytokine levels (p<0.05) were determined by ELISA.
Decreased macrophage infiltration and F4/80 and MCP-1 expression in the visceral adipose tissue of HFD Y680 rats (p<0.5), together with a higher pAkt/Akt expression (p<0.05) were also observed by immunofluorescence and immunoblotting.
A significant increase in glucagon (Gcg) and PYY mRNA levels in distal ileum of HFD Y680 rats (p<0.05) were also detected.
In the second approach, we determined that yacon supplementation potentiates the effects of the HFD reversion to a standard diet.
In conclusion, yacon showed antiobesity properties by inhibiting adipogenesis and improving the visceral adipose tissue function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Honoré, Stella Maris& Grande, Maria Virginia& Gomez Rojas, Jorge& Sánchez, Sara Serafina. 2018. Smallanthus sonchifolius (Yacon) Flour Improves Visceral Adiposity and Metabolic Parameters in High-Fat-Diet-Fed Rats. Journal of Obesity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1195986
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Honoré, Stella Maris…[et al.]. Smallanthus sonchifolius (Yacon) Flour Improves Visceral Adiposity and Metabolic Parameters in High-Fat-Diet-Fed Rats. Journal of Obesity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1195986
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Honoré, Stella Maris& Grande, Maria Virginia& Gomez Rojas, Jorge& Sánchez, Sara Serafina. Smallanthus sonchifolius (Yacon) Flour Improves Visceral Adiposity and Metabolic Parameters in High-Fat-Diet-Fed Rats. Journal of Obesity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1195986
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195986
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر