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Smallanthus sonchifolius (Yacon) Flour Improves Visceral Adiposity and Metabolic Parameters in High-Fat-Diet-Fed Rats
المؤلفون المشاركون
Honoré, Stella Maris
Grande, Maria Virginia
Gomez Rojas, Jorge
Sánchez, Sara Serafina
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-28
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Smallanthus sonchifolius (yacon), a native plant of South America, was observed to improve lipid profile in rodents and humans.
This study aimed to investigate the antiobesity properties of yacon roots in a high-fat-diet (HFD) model and the underlying mechanisms.
A total of 30 Wistar male rats were divided into five groups (n=6): the standard chow diet (SD) group was fed a SD; the HFD group was fed a HFD; and the HFD Y340 and HFD Y680 groups were fed a HFD plus yacon flour (340 and 680 mg FOS/kg b.
w./day, respectively).
HFD Y340 and HFD Y680 rats exhibited marked attenuation of weight gain, a decrease in visceral fat pad weight, a restoration of the serum lipid profile and atherogenic index in a dose-dependent manner, being the higher dose more effective (p<0.05).
In addition, we found that HFD Y680 rats showed lower glucose and insulin levels, improved glucose tolerance, and insulin sensitivity (p<0.5).
A downregulation of several adipocyte specific-transcription factors, including peroxisome proliferator-activated receptor gamma2 (PPAR-γ2), CCAAT/enhancer binding protein a (C/EBP-a) and activating protein (aP2) mRNA levels, was determined in the visceral adipose tissue of HFD Y680 rats (p<0.05).
An improvement of adipokine profile in HFD Y680 rats and decreased serum proinflammatory cytokine levels (p<0.05) were determined by ELISA.
Decreased macrophage infiltration and F4/80 and MCP-1 expression in the visceral adipose tissue of HFD Y680 rats (p<0.5), together with a higher pAkt/Akt expression (p<0.05) were also observed by immunofluorescence and immunoblotting.
A significant increase in glucagon (Gcg) and PYY mRNA levels in distal ileum of HFD Y680 rats (p<0.05) were also detected.
In the second approach, we determined that yacon supplementation potentiates the effects of the HFD reversion to a standard diet.
In conclusion, yacon showed antiobesity properties by inhibiting adipogenesis and improving the visceral adipose tissue function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Honoré, Stella Maris& Grande, Maria Virginia& Gomez Rojas, Jorge& Sánchez, Sara Serafina. 2018. Smallanthus sonchifolius (Yacon) Flour Improves Visceral Adiposity and Metabolic Parameters in High-Fat-Diet-Fed Rats. Journal of Obesity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1195986
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Honoré, Stella Maris…[et al.]. Smallanthus sonchifolius (Yacon) Flour Improves Visceral Adiposity and Metabolic Parameters in High-Fat-Diet-Fed Rats. Journal of Obesity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1195986
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Honoré, Stella Maris& Grande, Maria Virginia& Gomez Rojas, Jorge& Sánchez, Sara Serafina. Smallanthus sonchifolius (Yacon) Flour Improves Visceral Adiposity and Metabolic Parameters in High-Fat-Diet-Fed Rats. Journal of Obesity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1195986
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1195986
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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