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Efficacy Comparison of Intravitreal Anti-VEGF Therapy for Three Subtypes of Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Li, Jianqing
Xu, Jiayi
Chen, Yiyi
Zhang, Jiaju
Cao, Yihong
Lu, Pei-Rong
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-23
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Purpose.
Intravitreal antivascular endothelial growth factor (anti-VEGF) therapy has been widely used for the treatment of neovascularization (NV) secondary to age-related macular degeneration (AMD).
This study aimed to compare the efficacy among different subtypes of neovascular age-related macular degeneration (nAMD).
Methods.
PubMed, Embase, and the Cochrane Library were searched for eligible studies.
We performed meta-analysis using Review Manager 5.3 and Stata/SE 12.0.
Results.
A total of 24 studies met our inclusion criteria and were included in the systematic review.
At 3 months, the mean logarithm of the minimum angle of resolution (logMAR) improvements were −0.09, −0.18, and −0.23 for type 1, 2, and 3, respectively, while the mean macular thickness (MT) changes were −104.83, −130.76, and −196.29 μm.
At 12 months, the mean changes in Early Treatment of Diabetic Retinopathy Study (ETDRS) letters were 6.38, 8.12, and 9.37, while the MT decrease was 126.51, 126.52, and 139.85 μm, respectively.
However, statistically significant difference was only found between type 1 and 3 in vision improvement, both in the short term (p=0.0002) and long term (p=0.01).
Conclusions.
The reactivity to VEGF inhibitors varied among different subtypes of nAMD.
The efficacy of intravitreal anti-VEGF therapy in type 3 nAMD was statistically better than type 1 when considering vision improvement at 3 and 12 months.
Thus, the lesion subtype is a predictor for the treatment outcome which can help guide prognosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jianqing& Xu, Jiayi& Chen, Yiyi& Zhang, Jiaju& Cao, Yihong& Lu, Pei-Rong. 2018. Efficacy Comparison of Intravitreal Anti-VEGF Therapy for Three Subtypes of Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1196170
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jianqing…[et al.]. Efficacy Comparison of Intravitreal Anti-VEGF Therapy for Three Subtypes of Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis. Journal of Ophthalmology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1196170
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jianqing& Xu, Jiayi& Chen, Yiyi& Zhang, Jiaju& Cao, Yihong& Lu, Pei-Rong. Efficacy Comparison of Intravitreal Anti-VEGF Therapy for Three Subtypes of Neovascular Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1196170
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196170
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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