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Association of Optic Neuritis with CYP4F2 Gene Single Nucleotide Polymorphism and IL-17A Concentration
المؤلفون المشاركون
Vilkeviciute, Alvita
Liutkeviciene, Rasa
Glebauskiene, Brigita
Kriauciuniene, Loresa
Banevicius, Mantas
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-03-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
The aetiology and pathophysiology of optic neuritis (ON) is not absolutely clear but genetic and inflammatory factors may be also involved in its development.
The aim of the present study was to determine the influence of single nucleotide polymorphism (SNP) of CYP4F2 (rs1558139) and serum levels of IL-17A on ON development.
Materials and Methods.
Forty patients with ON and 164 control subjects were evaluated.
Patients were divided by gender, also ON patients were divided into two subgroups: ON with and without multiple sclerosis (MS).
CYP4F2 rs1558139 was genotyped using real-time PCR.
Serum IL-17A levels were measured using ELISA IL-17A kits.
Results.
We found that A/A genotype of CYP4F2 rs1558139 was statistically significantly more frequent in men with ON and MS than in women: 57.1% versus 0%, p=0.009.
Also, allele A was statistically significantly more frequent in men with ON and MS than in women: 71.4% versus 37.5%, p=0.044.
Serum levels of IL-17A were higher in ON group than in control group: (median, IQR): 20.55 pg/ml, 30.66 pg/ml versus 8.97 pg/ml, 6.24 pg/ml, p<0.001.
Conclusion.
The higher IL-17A levels were found to be associated with ON, while allele A at rs1558139 was associated only with ON with MS in male patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Banevicius, Mantas& Vilkeviciute, Alvita& Glebauskiene, Brigita& Kriauciuniene, Loresa& Liutkeviciene, Rasa. 2018. Association of Optic Neuritis with CYP4F2 Gene Single Nucleotide Polymorphism and IL-17A Concentration. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1196206
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Banevicius, Mantas…[et al.]. Association of Optic Neuritis with CYP4F2 Gene Single Nucleotide Polymorphism and IL-17A Concentration. Journal of Ophthalmology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1196206
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Banevicius, Mantas& Vilkeviciute, Alvita& Glebauskiene, Brigita& Kriauciuniene, Loresa& Liutkeviciene, Rasa. Association of Optic Neuritis with CYP4F2 Gene Single Nucleotide Polymorphism and IL-17A Concentration. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1196206
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196206
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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