Effects of Smoking on Outcomes of Antivascular Endothelial Growth Factor Therapy in Patients with Neovascular Age-Related Macular Degeneration Smoking and Anti-VEGF Therapy in nAMD
المؤلفون المشاركون
Miki, Atsushi
Goto, Katsutoshi
Kiryu, Junichi
Kamao, Hiroyuki
Mito, Yumi
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-11-12
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
To evaluate the effect of smoking on the outcome of antivascular endothelial growth factor (VEGF) therapy in patients with neovascular age-related macular degeneration (nAMD).
Methods.
This retrospective case-control study included 64 eyes in 59 patients with treatment-naïve nAMD.
Smoking habits were obtained from hospital records and patient recall.
The patients were divided into ever-smokers and never-smokers.
The patients were treated with ranibizumab or aflibercept for at least 1 year.
Outcome measures were best-corrected visual acuity (BCVA), central retinal thickness (CRT) at the fovea, subfoveal choroidal thickness (SCT), and number of injections received.
Results.
There were no statistically significant differences in BCVA, CRT, or SCT changes between ever-smokers and never-smokers.
The number of injections received was significantly higher in ever-smokers with a history of heavy smokers (never-smokers vs.
heavy smokers: 5.3 ± 2.6/year vs.
7.3 ± 2.5/year; P=0.048 and mild smokers vs.
heavy smokers: 5.2 ± 2.5/year vs.
7.3 ± 2.5/year; P=0.043).
There was no significant difference in the baseline CRT or presence of atrophic retinal pigment epithelium in the fellow eyes of patients with nAMD according to smoking status; however, the baseline CRT in eyes with nAMD was significantly thinner in ever-smokers than in never-smokers (P=0.02).
Conclusion.
The anti-VEGF therapy was frequently required in nAMD patients with a history of heavy smoking.
Heavy smoking could cause poor therapeutic response in nAMD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kamao, Hiroyuki& Goto, Katsutoshi& Mito, Yumi& Miki, Atsushi& Kiryu, Junichi. 2018. Effects of Smoking on Outcomes of Antivascular Endothelial Growth Factor Therapy in Patients with Neovascular Age-Related Macular Degeneration Smoking and Anti-VEGF Therapy in nAMD. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1196255
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kamao, Hiroyuki…[et al.]. Effects of Smoking on Outcomes of Antivascular Endothelial Growth Factor Therapy in Patients with Neovascular Age-Related Macular Degeneration Smoking and Anti-VEGF Therapy in nAMD. Journal of Ophthalmology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1196255
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kamao, Hiroyuki& Goto, Katsutoshi& Mito, Yumi& Miki, Atsushi& Kiryu, Junichi. Effects of Smoking on Outcomes of Antivascular Endothelial Growth Factor Therapy in Patients with Neovascular Age-Related Macular Degeneration Smoking and Anti-VEGF Therapy in nAMD. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1196255
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196255
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر