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Effects of Redox Modulation on Cell Proliferation, Viability, and Migration in Cultured Rat and Human Tendon Progenitor Cells
المؤلفون المشاركون
Hung, Leung-Kim
Chan, Kai-Ming
Lee, Yuk Wa
Fu, Sai Chuen
Yeung, Man Yi
Lau, Chun Man Lawrence
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Tendon healing is slow and usually results in inferior fibrotic tissue formation.
Recently, application of tendon derived stem cells (TDSCs) improved tendon healing in animal studies.
In a chicken model, local injection of antioxidants reduced tendon adhesion after tendon injury.
An in vitro study demonstrated that supplementation of H2O2 reduced tenogenic marker expression in TDSCs.
These findings suggested that the possibility of TDSCs is involved in tendon healing and the cellular activities of TDSCs might be affected by oxidative stress of the local environment.
After tendon injury, oxidative stress is increased.
Redox modulation might affect healing outcomes via affecting cellular activities in TDSCs.
To study the effect of oxidative stress on TDSCs, the cellular activities of rat/human TDSCs were measured under different dosages of vitamin C or H2O2 in this study.
Lower dose of vitamin C increased cell proliferation, viability and migration; H2O2 affected colony formation and suppressed cell migration, cell viability, apoptosis, and proliferation.
Consistent with previous studies, oxidative stresses (H2O2) affect both recruitment and survival of TDSCs, while the antioxidant vitamin C may exert beneficial effects at low doses.
In conclusion, redox modulation affected cellular activities of TDSCs and might be a potential strategy for tendon healing treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Yuk Wa& Fu, Sai Chuen& Yeung, Man Yi& Lau, Chun Man Lawrence& Chan, Kai-Ming& Hung, Leung-Kim. 2017. Effects of Redox Modulation on Cell Proliferation, Viability, and Migration in Cultured Rat and Human Tendon Progenitor Cells. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1196282
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Yuk Wa…[et al.]. Effects of Redox Modulation on Cell Proliferation, Viability, and Migration in Cultured Rat and Human Tendon Progenitor Cells. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1196282
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Yuk Wa& Fu, Sai Chuen& Yeung, Man Yi& Lau, Chun Man Lawrence& Chan, Kai-Ming& Hung, Leung-Kim. Effects of Redox Modulation on Cell Proliferation, Viability, and Migration in Cultured Rat and Human Tendon Progenitor Cells. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1196282
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196282
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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