Oleic Acid and Hydroxytyrosol Inhibit Cholesterol and Fatty Acid Synthesis in C6 Glioma Cells
المؤلفون المشاركون
Priore, Paola
Gnoni, Antonio
Natali, Francesco
Testini, Mariangela
Gnoni, Gabriele V.
Siculella, Luisa
Damiano, Fabrizio
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-24
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Recently, the discovery of natural compounds capable of modulating nervous system function has revealed new perspectives for a healthier brain.
Here, we investigated the effects of oleic acid (OA) and hydroxytyrosol (HTyr), two important extra virgin olive oil compounds, on lipid synthesis in C6 glioma cells.
OA and HTyr inhibited both de novo fatty acid and cholesterol syntheses without affecting cell viability.
The inhibitory effect of the individual compounds was more pronounced if OA and HTyr were administered in combination.
A reduction of polar lipid biosynthesis was also detected, while triglyceride synthesis was marginally affected.
To clarify the lipid-lowering mechanism of these compounds, their effects on the activity of key enzymes of fatty acid biosynthesis (acetyl-CoA carboxylase-ACC and fatty acid synthase-FAS) and cholesterologenesis (3-hydroxy-3-methylglutaryl-CoA reductase-HMGCR) were investigated in situ by using digitonin-permeabilized C6 cells.
ACC and HMGCR activities were especially reduced after 4 h of 25 μM OA and HTyr treatment.
No change in FAS activity was observed.
Inhibition of ACC and HMGCR activities is corroborated by the decrease of their mRNA abundance and protein level.
Our results indicate a direct and rapid downregulatory effect of the two olive oil compounds on lipid synthesis in C6 cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Priore, Paola& Gnoni, Antonio& Natali, Francesco& Testini, Mariangela& Gnoni, Gabriele V.& Siculella, Luisa…[et al.]. 2017. Oleic Acid and Hydroxytyrosol Inhibit Cholesterol and Fatty Acid Synthesis in C6 Glioma Cells. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1196340
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Priore, Paola…[et al.]. Oleic Acid and Hydroxytyrosol Inhibit Cholesterol and Fatty Acid Synthesis in C6 Glioma Cells. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1196340
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Priore, Paola& Gnoni, Antonio& Natali, Francesco& Testini, Mariangela& Gnoni, Gabriele V.& Siculella, Luisa…[et al.]. Oleic Acid and Hydroxytyrosol Inhibit Cholesterol and Fatty Acid Synthesis in C6 Glioma Cells. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1196340
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196340
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر