Treatment of Diabetic Macular Edema with Intravitreal Antivascular Endothelial Growth Factor and Prompt versus Deferred Focal Laser during Long-Term Follow-Up and Identification of Prognostic Retinal Markers
المؤلفون المشاركون
Gleiss, A.
Vécsei-Marlovits, Pia Veronika
Weingessel, Birgit
Miháltz, Kata
Sulzbacher, Florian
Schütze, Christopher
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-10-01
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Purpose.
Long-term follow-up of patients with diabetic macular edema (DME) treated with intravitreal antivascular endothelial growth factor (anti-VEGF) combined focal laser and identification of prognostic morphological characteristics.
Methods.
Prospective clinical trial (50 treatment-naive eyes) with DME randomized 1 : 1 receiving intravitreal ranibizumab (0.5 mg/0.05 ml) and prompt grid laser compared with ranibizumab and deferred laser.
Morphological characteristics potentially relevant for prognosis were assessed at baseline, month 6, month 9, and years 1, 2, 3, 4, and 5 of follow-up.
Results.
Although functional results were slightly higher in the prompt group at week 12 (0.5; 20/40 Snellen (SD = 0.04, 0.3 logMAR) versus 0.4; 20/50 Snellen (SD = 0.04, logMAR: 0.4), p=0.4) and month 9 (prompt group: 0.5; 20/40 Snellen (SD = 0.03, 0.3 logMAR) versus deferred group: 0.4; 20/50 Snellen (SD = 0.04, 0.4 logMAR), p=0.4), these were statistically insignificant.
There was no significant benefit regarding functionality during long-term follow-up in the prompt group compared to the deferred group.
BCVA in the eyes with clusters of hyperreflective foci in the central macular region was inferior compared with the eyes without these alterations at year 5 (0.39; 20/50 Snellen, (SD = 0.25, 0.4 logMAR) versus 0.63; 20/80 Snellen (SD = 0.22, 0.2 logMAR), p<0.01).
Conclusion.
Grid laser and ranibizumab therapy are effective in DME management during the long-term follow-up.
Intraretinal hyperreflective material in SD-OCT is negatively related to BCVA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Weingessel, Birgit& Miháltz, Kata& Gleiss, A.& Sulzbacher, Florian& Schütze, Christopher& Vécsei-Marlovits, Pia Veronika. 2018. Treatment of Diabetic Macular Edema with Intravitreal Antivascular Endothelial Growth Factor and Prompt versus Deferred Focal Laser during Long-Term Follow-Up and Identification of Prognostic Retinal Markers. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1196422
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Weingessel, Birgit…[et al.]. Treatment of Diabetic Macular Edema with Intravitreal Antivascular Endothelial Growth Factor and Prompt versus Deferred Focal Laser during Long-Term Follow-Up and Identification of Prognostic Retinal Markers. Journal of Ophthalmology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1196422
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Weingessel, Birgit& Miháltz, Kata& Gleiss, A.& Sulzbacher, Florian& Schütze, Christopher& Vécsei-Marlovits, Pia Veronika. Treatment of Diabetic Macular Edema with Intravitreal Antivascular Endothelial Growth Factor and Prompt versus Deferred Focal Laser during Long-Term Follow-Up and Identification of Prognostic Retinal Markers. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1196422
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196422
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر