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miR-128 Is Implicated in Stress Responses by Targeting MAFG in Skeletal Muscle Cells
المؤلفون المشاركون
Esposito, Giovanni
Caggiano, Rocco
Cattaneo, Fabio
Moltedo, Ornella
Perrino, Cinzia
Trimarco, Bruno
Ammendola, Rosario
Faraonio, Raffaella
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-12
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
MAFG (v-Maf avian musculoaponeurotic fibrosarcoma oncogene homolog G) is a bZIP-type transcriptional regulator that belongs to the small MAF (sMAFs) protein family.
By interacting with other bZIP transcription factors, sMAFs can form homo- and heterodimers governing either repressive or activating transcriptional functions.
As heterodimeric partner of Nrf2, MAFG positively influences the ARE-dependent antioxidant/xenobiotic pathways, at least in condition of a correct MAFG:Nrf2 balance.
MicroRNAs (miRs) participate to different regulatory networks being involved as fine-tuning regulators of gene expression.
However, the connections between cellular surveillance to stresses mediated by MAFG:Nrf2 and miR regulations are not well understood.
Here, we explored the impact of miR-128 in expression of genes related to stress response.
Bioinformatic predictions coupled with functional analysis revealed the presence of miR-128 binding site in the 3′UTR of MAFG.
Ectopic miR-128 expression correlated with reduced expression of endogenous MAFG-dependent genes and negatively affected ARE-mediated molecular phenotype based on Nrf2 activity.
Indeed, miR-128 impairs redox-dependent pathways induced in response to oxidative stress.
Moreover, in condition of hypoxia, MAFG induction correlated with reduced levels of miR-128.
This lead to increased mRNA levels of HMOX-1 and x-CT for blunting stress.
Overall, these findings identify MAFG as novel direct target of miR-128.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Caggiano, Rocco& Cattaneo, Fabio& Moltedo, Ornella& Esposito, Giovanni& Perrino, Cinzia& Trimarco, Bruno…[et al.]. 2017. miR-128 Is Implicated in Stress Responses by Targeting MAFG in Skeletal Muscle Cells. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1196488
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Caggiano, Rocco…[et al.]. miR-128 Is Implicated in Stress Responses by Targeting MAFG in Skeletal Muscle Cells. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1196488
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Caggiano, Rocco& Cattaneo, Fabio& Moltedo, Ornella& Esposito, Giovanni& Perrino, Cinzia& Trimarco, Bruno…[et al.]. miR-128 Is Implicated in Stress Responses by Targeting MAFG in Skeletal Muscle Cells. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1196488
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196488
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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