Pterostilbene 4′-β-Glucoside Protects against DSS-Induced Colitis via Induction of Tristetraprolin

الملخص EN

Pterostilbene, a dimethyl ester analog of resveratrol, has anti-inflammatory and antioxidative effects and alters cell proliferation.

Tristetraprolin (TTP) promotes the degradation of proinflammatory mediators via binding to adenosine and uridine- (AU-) rich elements (ARE) located in the 3′-untranslated regions of mRNAs.

Here, we utilized pterostilbene 4′-β-glucoside (4-PG), a compound derived from pterostilbene, to investigate whether it has anti-inflammatory effects on dextran sulfate sodium- (DSS-) induced colitis via TTP enhancement.

TTP expression was increased in 4-PG dose- and time-dependent manners in RAW264.7 cells.

The production of proinflammatory cytokine, such as TNF-α, was reduced by 4-PG in vitro.

To investigate the role of TTP in the anti-inflammatory effects of 4-PG, we used DSS-induced colitis in TTP WT and KO mice as models.

The expression levels of TTP and proinflammatory cytokines were determined in serum and colon tissue.

4-PG increased the expression of TTP while suppressing proinflammatory cytokines both in vitro and in vivo.

These findings suggest that treatment with 4-PG mediates the anti-inflammatory effects of 4-PG on DSS-induced colitis via enhancing TTP expression.